Hematology Flashcards
MCV values?
>100 - Macrocytic
80-100 - Normocytic
<80 - Microcytic
What are signs and symptoms of anemia?
Fatigue, tachycardia, hepatosplenomegaly, DOE, pallor, bone tenderness.
Majority of the iron absorption occurs in the?
Duodenum
Once absorbed, what is iron transferred by?
Transferrin
Iron is stored as ___1___. Stored in the ____4___
Stored as ferratin in the liver, spleen, bone marrow, muscle
What type of anemia is iron deficiency anemia?
Microcytic hypochromic anemia - may be normocytic early on.
Causes of iron deficiency anemia?
Insufficient dietary intake of iron, poor absorption of iron, or chronic blood loss
More common in women - menstruation
S/s of iron deficiency anemia?
Tachycardia, DOE, fatigue
Pale skin and mucosa
Brittle nails
Angular chelitis - on corners of mouth
Pruritius
Pica
Anxiety, tingling, numbness
The most sensitive iron study is?
Ferratin - stored iron, first lab to become low.
Total iron binding capacity is the ___ most sensitive. What does it measure? What value would it have in IDA?
Second most sensitive - measures capacity to bind to iron.
Indicative of iron deficiency anemia if HIGH
Serum iron could be ____ or normal in IDA
low
Transferrin saturation expresses? What value would it have in IDA?
Expresses how much serum iron is bound.
Indicative of IDA if LOW
Total lab profile for IDA? HgB, MCV, RDW, Ferratin, TIBC/transferrin, Serum FE, % saturation
HgB - decreased
HCV - decreased
RDW - Increased
Ferratin - decreased
TIBC - increased
Serum FE - low or normal
% saturation - low.
Treatment of IDA?
Diet - red meat, spinach, lentils
Ferrous sulfate - 325mg TID - 10mg absorbed
Find source of bleeding if that is the cause.
