Hematology Flashcards
What is langerhans histocytosis?
• what are some signs and symptoms?
• Cell markers?
• Histological marker?
Proliferative Disroders of Dendritic (langerhans cells or any other phagocytic cell) Presentation:
• presents in child as bone lesion an skin rash with lethargy
• Otitis media that is recurrent with a mass involving the mastoid
Cell Marker:
• CD1a
• S100 (mesodermal origin)
Histo:
• Birbeck Granules (tennis rackets on EM)
• Eosinophilic Histiocytes
What is the genome of EBV like?
Double Stranded DNA virus
**Major association with Burkett’s in Africa
What is a potential coagulation defect that can result from chronic antibiotic use and why?
Vitamin K deficiency can result from antibiotic use and lead to deficient gamma-carboxylation of factors II, VII, IX, and X, Proteins C and S to cause bleeding disorders.
ENTERIC BACTERIA ARE VIAL TO MAKING OUR VITAMIN K.
**Rarely occurs but can cause splinter hemorrhages**
Describe Direct Coombs
Anti-IgG antibody is added to patients RBCs, if they are coated in autoimmune IgG then RBCs will lyse
What is the cause of pernicious anemia?
Intrinsic factor (released from parietal cells in stomach) complexes with B12 in the duodenum (after pancreatic enzymes dissolve R-protein that originally binds B12) then travels to the Ileum where it is endocytosed by enterocytes.
Positive Schilling Test confirms this dx.
In Rh negative mothers who are having their 2nd Rh positive child without any hospital treatments, what do you expect to see in the liver of the 2nd child?
If the mother has not been treated, the child will get erythroblastosis fetalis and will do extramedullary hematopoiesis in the liver.
Histo will show megakaryocytes and myeliod precursors in sinus tracts
