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Step 1 Pharm > Hematology > Flashcards

Hematology Flashcards

1
Q

heparin

A

d

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2
Q

enoxaparin

A

d

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3
Q

dalteparin

A

d

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4
Q

fondaparinux

A

d

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5
Q

argatroban

A

b

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6
Q

bivalirudin

A

d

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7
Q

dabigatran

A

d

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8
Q

warfarin

A

d

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9
Q

apixaban

A

d

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10
Q

rivaroxaban

A

d

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11
Q

alteplase (tPa)

A

Thrombolytic

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12
Q

reteplase (rPa)

A

thrombolytic

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13
Q

streptokinase

A

thrombolytic

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14
Q

tenecteplase TNK-tPA

A

thrombolytic

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15
Q

Aspirin

A

COX inhibitor

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16
Q

clopidogrel

A

ADP receptor inhibitor

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17
Q

prasugrel

A

ADP receptor inhibitor

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18
Q

ticagrelor

A

ADP receptor inhibitor

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19
Q

ticlopidine

A

ADP receptor inhibitor

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20
Q

cilostazol

A

phosphodiesterase III inhibitor

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21
Q

dipyridamole

A

phosphodiesterase III inhibitor

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22
Q

abciximab

A

GP IIb/IIIa inhibitor

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23
Q

eptifibatide

A

GP IIb/IIIa inhibitor

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24
Q

tirofiban

A

GP IIb/IIIa inhibitor

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25
Q

azithioprine

A

purine thiol analog

26
Q

6-mercaptopurine (6-MP)

A

purine thiol analog

27
Q

6-thioguanine

A

purine thiol analog

28
Q

Cladribine

A

Purine analog

29
Q

cytarabine (arabinofuranosyl cytidine)

A

pyrimidine analog

30
Q

5-fluoruracil (5-FU)

A

pyrimidine analog; bioactivated

31
Q

methotrexate

A

folic acid analog

DHFR inhibitor

32
Q

bleomycin

A

antitumor - induces free radical formation –> DNA stran breaks

33
Q

dactinomycin

A

antitumor

intercalates in DNA

34
Q

doxorubicin

A

generates free radicals

Intercalate in DNA

35
Q

daunorubicine

A

generates free radicals

Intercalate in DNA

36
Q

busulfan

A

cross-links DNA

37
Q

cyclophosphamide

A

cross links DNA at guanine

38
Q

ifosfamide

A

cross-links DNA at guanine

39
Q

carmustine

A

require bioactivation

40
Q

lomustine

A

require bioactivation

41
Q

semustine

A

require bioactivation

42
Q

streptozocin

A

require bioactivation

43
Q

paclitaxel

A

stabilizes polymerized microtubules in M phase

44
Q

vincristine

A

vinca alkaloid binds B-tubulin

inhibits polymerization

45
Q

vinblastine

A

vinca alkaloid binds B-tubulin

inhibits polymerization

46
Q

Cisplatin

A

Cross-links DNA

47
Q

carboplatin

A

Cross-links DNA

48
Q

Etoposide

A

inhibits topoisomerase II

49
Q

teniposide

A

inhibits topoisomerase II

50
Q

irinotecan

A

inhibits topoisomerase I

51
Q

topotecan

A

Inhibits topoisomerase I

52
Q

hydroxyurea

A

inhibits ribonucleotide reductase -> inhibits DNA synthesis

53
Q

prednisone

A

alters gene transcription

54
Q

prednisolone

A

alters gene transcription

55
Q

bevacizumab

A

monoclonal Ab vs VEGF

56
Q

Erlotinib

57
Q

Imatinib

A

TK inhibitor of BCR-ABL

philadelphia chromosome fusion gene in CML

58
Q

rituximab

A

monoclonal Ab vs CD20

59
Q

tamoxifen

A

selective estrogen receptor modulators

60
Q

raloxifene

A

selective estrogen receptor modulators

61
Q

trastuzumab

A

monoclonal Ab vs HER2

62
Q

vemurafenib

A

small molecule inhibitor of BRAF oncogene

Step 1 Pharm (10 decks)

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