Hematology Flashcards
1
Q
heparin
A
d
2
Q
enoxaparin
A
d
3
Q
dalteparin
A
d
4
Q
fondaparinux
A
d
5
Q
argatroban
A
b
6
Q
bivalirudin
A
d
7
Q
dabigatran
A
d
8
Q
warfarin
A
d
9
Q
apixaban
A
d
10
Q
rivaroxaban
A
d
11
Q
alteplase (tPa)
A
Thrombolytic
12
Q
reteplase (rPa)
A
thrombolytic
13
Q
streptokinase
A
thrombolytic
14
Q
tenecteplase TNK-tPA
A
thrombolytic
15
Q
Aspirin
A
COX inhibitor
16
Q
clopidogrel
A
ADP receptor inhibitor
17
Q
prasugrel
A
ADP receptor inhibitor
18
Q
ticagrelor
A
ADP receptor inhibitor
19
Q
ticlopidine
A
ADP receptor inhibitor
20
Q
cilostazol
A
phosphodiesterase III inhibitor
21
Q
dipyridamole
A
phosphodiesterase III inhibitor
22
Q
abciximab
A
GP IIb/IIIa inhibitor
23
Q
eptifibatide
A
GP IIb/IIIa inhibitor
24
Q
tirofiban
A
GP IIb/IIIa inhibitor
25
azithioprine
purine thiol analog
26
6-mercaptopurine (6-MP)
purine thiol analog
27
6-thioguanine
purine thiol analog
28
Cladribine
Purine analog
29
cytarabine (arabinofuranosyl cytidine)
pyrimidine analog
30
5-fluoruracil (5-FU)
pyrimidine analog; bioactivated
31
methotrexate
folic acid analog
| DHFR inhibitor
32
bleomycin
antitumor - induces free radical formation --> DNA stran breaks
33
dactinomycin
antitumor
| intercalates in DNA
34
doxorubicin
generates free radicals
| Intercalate in DNA
35
daunorubicine
generates free radicals
| Intercalate in DNA
36
busulfan
cross-links DNA
37
cyclophosphamide
cross links DNA at guanine
38
ifosfamide
cross-links DNA at guanine
39
carmustine
require bioactivation
40
lomustine
require bioactivation
41
semustine
require bioactivation
42
streptozocin
require bioactivation
43
paclitaxel
stabilizes polymerized microtubules in M phase
44
vincristine
vinca alkaloid binds B-tubulin
| inhibits polymerization
45
vinblastine
vinca alkaloid binds B-tubulin
| inhibits polymerization
46
Cisplatin
Cross-links DNA
47
carboplatin
Cross-links DNA
48
Etoposide
inhibits topoisomerase II
49
teniposide
inhibits topoisomerase II
50
irinotecan
inhibits topoisomerase I
51
topotecan
Inhibits topoisomerase I
52
hydroxyurea
inhibits ribonucleotide reductase -> inhibits DNA synthesis
53
prednisone
alters gene transcription
54
prednisolone
alters gene transcription
55
bevacizumab
monoclonal Ab vs VEGF
56
Erlotinib
EGFR TKR
57
Imatinib
TK inhibitor of BCR-ABL
| philadelphia chromosome fusion gene in CML
58
rituximab
monoclonal Ab vs CD20
59
tamoxifen
selective estrogen receptor modulators
60
raloxifene
selective estrogen receptor modulators
61
trastuzumab
monoclonal Ab vs HER2
62
vemurafenib
small molecule inhibitor of BRAF oncogene
