Hematology

Question 1

Follicular Lymphoma

Answer 1

• CD10, CD19, CD20

- t(14,18)- bcl-2 activation

Question 2

SLL/CLL

Answer 2

CD5, CD19, CD20, CD23, CD43

• CLL “Smudge cells” in PB
• Coombs + spherocytosis in CLL

SLL within LN- small kids stay home
CLL from Bone marrow–>blood

Question 3

Burkitts Lymphoma

Answer 3

• CD10, CD19, CD20, sIg
• t(8;14) > t(2;8), t(8;22)
• c-myc activation
• Non-Hodgkins
• EBV

Question 4

Hairy Cell Leukemia

Answer 4

CD11c, CD20, CD25, CD103

cells are trapped, you use a trap stain.

Question 5

Classical HL

Answer 5

CD15, CD30

• Nodular sclerosing [RS cells=Lacunar cells]- collagen bands
• mixed cellularity [has tissue eosinophilia due to IL-5]-EBV+
• Lymphocyte depleted [RS cells=Bizarre RS cells]-EBV+/associated w/ aids, Oral Hair Leukoplakia
• Lymphocyte Rich- best prognosis

Question 6

Variant HL (Lymphocyte predominant)

Answer 6

CD20, CD45
-RS cells= L&H or Popcorn cells
-Large nodules but no collagen
- may transform to DLBL (richter transformation)
-

Question 7

AML

Answer 7

-t(15;17)- DIC, RARalpa-PML

Question 8

CML

Answer 8

t(9;22)-good prognosis
-Philedelphia chromosome
(bcr-abl hybrid)
-Philidelphia CreaML chees

Question 9

PNH

Answer 9

Complement attack RBC.
PIGA mutation–> no PIGA to synthesize GPI–> No protection from complement attack

CD55 and CD59 absent

Question 10

Mantle cell Lymphoma

Answer 10

t(11;14)

- cyclin D1 activation

Question 11

EWing

Answer 11

t(11;22)

t(21;22)

Question 12

ALL

Answer 12

• CD10, CD19, CD20/ CD2, CD8
  Good prognosis: t(12;21)
  Bad prognosis; t(9;22), t(11;var)MLL, t(8;14) MYC/IGH burkitt like
• Ass. w/ Down-syndrome***
• Good prognosis: 2-10yr old girl, B-cell, hyperploidy and less than 100,000 WBCs
• T-Cell, NOTCH-1 expression (mediastinal lymphadenopathy on CXR-

Question 13

diseases that transform to AML-t(15;17)

Answer 13

Myeloproliferative disorders [Blast crisis]
- CML-->most common
- MDS
- Essential thrombocytosis
- polycythemia vera
- myelofibrosis
CLL
PNH

Question 14

Diseases caused by EBV

Answer 14

Burkitt's Lymphoma
Infective Mononucleiosis
Oral Hairy Leukoplakia (Aids, Lympocyte depleted w/bizarre RS cells)
Nasopharyngeal carcinoma
Hodgkins Lymphoma
- mixed cellularity
- Lymphocyte depleted

Question 15

Polcythemia (EPO)

Answer 15

• Renal Cell Carcinoma
• thymoma
• hemangioblastoma
• hepatocellular carcinoma
• leiomyoma
• pheochromocytoma

Question 16

Hematogenous spread

Answer 16

• Renal cell Ca
• Follicular Ca
• Hepatocellular Ca (Hepatoma)
• Choriocarcinoma

Question 17

Small Cell Lung carcinoma associations

Answer 17

• Cushings (ACTH)
• Hypercalcemia (PTHrP)
• Polycythemia (epo)
• SIADH (ADH)

Question 18

Marginal Zone Maltoma associations

Answer 18

Indolent lymphoma of small B cells,
associated with chronic inflammatory states:
- Harshimoto’s thyroiditis
- Sjorgen Syndrome (Dry eyes and mouth)
- H. pylori Gastritis (most common site)-treat for h.pylori
cured by resection

Question 19

cutaneous T-cell lymphoma

Answer 19

Mf and sezary’s syndrome (exopholiative erythroderma)

Question 20

Chronic Lymphoproliferative Disorders

Answer 20

• Chronic Lymphocytic Leukemia
• Hairy cell Leukemia
• Plasma cell dyscrasias

Question 21

Multiple Myeloma

Answer 21

t(4;14) FGFR3/IgH

-IL-6 (BM Fibroblasts and macrophages)