Hematology Flashcards
a HEME PREPARATION will repress
ALA synthase
Deficiency of what RBC enzymes has the same PP as G6PD?
glutathione reductase
Blood parameter not related to hemoglobin function
blood partial pressure of O2
Methemoglobinemia presentation
causes a dusky discoloration of the skin, functional anemia
absent expression of PECAM 1 gene will affect the neutrophilic function of
transmigration
Deficient flow pathway in G6PD
G6P to 6PG
To cause fetal hemolysis, maternal antibodies must be
predominantly IgM
Baby with megaloblastic anemia and high plasma homocysteine levels. Unable to form methylcobalamin. Synthesis of what substance is ML impaired?
methionine
Rx: long term anticoagulant to prevent venous thrombosis and resultant pulmonary embolism
warfarin
drug of choice for acute mgmy VT or TE
heparin
Patients with chronic hemolytic anemia are predisposed to
folic acid deficiency and macrocytic changes due to increased erythrocyte turnover
hemloytic anemia, a hypercoagulable state, and decreased blood counts
PNH
intrvascular hemolytic anemias are characterized by
decreased serum haptoglobin, increased Hgb, LDH, bilirubin
Most helpful for the consideration of spherocytosis
Increased MCHC, because of mild dehydration of the RBC
Spherocytosis- highest risk for developing
pigmented gallstones (complication of any hemolytic anemia)
Helpful in hx for T vs B cell ALL
T cell ALL presents as a mediastial mass that can cause respi sx, dysphagia, or superior vena cava syndrome
In the lungs, Hgb binds O2 and releases protons; tissues…
releases O2 and acquires protons
Raltegravir
integrase inhibitor that disrupts the ability of HIV to integrate its genome into the host cell’s chromosomes
NNRTI’s
arv drigs that do not require activation via intracellular phosphorylation.
more common NNRTI’s
nevirapine, efavirenz, delaviridine
Normal bell shaped curve: percentage within one standard deviation of the mean
68%
% of obs within two SD’s of mean
95%
within 3 SD’s of the mean
99.7%
Increases immediately once Vit B12 is administered
retic count
