Hematology

Question 1

Define TRALI

Answer 1

Hypoxemia and Bilateral Pulmonary Edema within 6 hours of transfusion, in the absence of other causes of heart failure

Question 2

Pathophysiology of TRALI

Answer 2

Donor plasma HLA 1 & 2 activating recipient neutrophils, leading to a lung immune response

Question 3

Define TACO

Answer 3

Pulmonary edema 2/2 fluid overload after transfusion