Hematology Flashcards
what is the best test to determine presence of anemia?
hemoglobin
anemia
decrease in hemoglobin
erythrocytosis
increase in hemoglobin
reference range of Hb in women
14 +/- 2
level of Hb considered to be anemia in women
<11 g/dL
reference range of Hb in men
16 +/- 2
level of Hb considered to be anemia in men
<13 g/dL
reference range for Hct in women
37-47%
reference range for Hct in men
40-54%
reference range for MCV
80-100 FL
what type of anemia is determined by an increase in MCH?
macrocytic anemias
what type of anemia is determined by a decrease in MCH?
microcytic and normocytic anemias
what is the earliest indicator for anemia?
red blood cell distribution width (RDW)
reference range for RDW
11-15%
definition of anicocytosis
abnormality in RBC size
hypochromatic
decreased MCHC
hyperchromatic
increased MCHC
polychromatic
reticulocytes, bluish coloration
reference range for WBC count
4500-11000
leukopenia
decrease in WBC count; viral infection
leukocytosis
increase in WBC count; bacterial infection, general inflammation
normal range for neutrophils
50-70%
neutrophilia
elevation of neutrophils
physiologic causes of neutrophilia
stress on body, pregnant, cold
pathologic causes of neutrophilia
bacterial infection, general inflammation
neutropenia
decrease in neutrophils
causes of neutropenia
viral infections, bone marrow disease
normal range of lymphocytes
20-40%
lymphocytosis
elevations of lymphocytes
causes of lymphocytosis
viral infections, stress, vaccinations
lymphocytopenia/lymphopenia
decrease in lymphocytes
causes of lymphopenia
bacterial infections
normal range for monocytes
2-10%
monocytosis
elevations of monocytes
causes of monocytosis
autoimmune; good sign–recovery from infection
normal range for eosinophils
~5%
eosinophilia
elevations in eosinophils
range for eosinophils in allergies
6-10%
range for eosinophils in parasite infection
24-30%
normal range of basophils
0-1%
basophilia
elevations in basophils
causes of basophilia
hypersensitivity reactions, myxedema, myeloproliferative conditions
CBC findings in bacterial infections
leukocytosis with neutrophilia
CBC findings in viral infections
leukopenia with lymphocytosis
reference range for platelet count
150000-400000
thrombocythemia
increase in platelets
thrombocytopenia
decrease in platelets
reference range for reticulocyte count
0.5-1.5%
general inflammation tests
ESR and CRP
poikilocytosis
cells are irregularly shaped
rouleux
stack of RBCs, interruption of negative charge
reference range for ESR in men under 40 yoa
1-15 mm/hr
reference range for ESR in women under 40 yoa
1-20 mm/hr
formula to calculate ESR in pts over 40 yoa
males: age/2
females: age +10/2
CRP
acute phase reactant, sensitive, rises in 4-6 hrs after onset, half-life of 5-7 hrs
spherocytes
slightly smaller RBCs, hereditary spherocytosis
schistocyte
fragment of RBCs; traumatic hemolytic anemia
bite cell
abnormal hemolysis, G6PD deficiency
sickle cell
sickle-shaped, sickle cell anemia
tear drop cell
myeloproliferative diseases (leukemias)
codocyte (target cell)
thalassemia
left shift
shift towards immaturity; infection