Hematology

Question 1

The symptom tetrad of:
1. Palpable purpura on buttocks, LE
2. Arthritis
3. Hematuria
4. Abdominal Pain
in Kids, would diagnose with:

Answer 1

Henoch-Schonlein Purpura

labs would also show IgA deposition

Question 2

Which medication can make you both Thrombocytopenic and Pro-Thrombotic?

Answer 2

Heparin.

Binds to platelets and makes them uncountable but also over activates them to make clots

Question 3

What do you do when you suspect HIT in a patient?

Answer 3

Immediately D/C heparin, start direct-thrombin-inhibitor, ultrasound lower extremities

Question 4

If you see the following pentad of symptoms:

1. Thrombocytopenia
2. Microangiopathic Hemolytic Anemia
3. Kidney Disease
4. Neurologic System abnormalities

Answer 4

TTP or HUS

Also, could see fever with TTP. and diarrhea in children

Question 5

Schistocytes seen on RBC smear, could indicate:

Answer 5

Microangiopathic hemolytic anemia.

RBCs are being destroyed by clogged mircovasculature and broken into smaller pieces.

Question 6

What type of thrombocytopenia is caused by both increased platelet destruction and decreased platelet formation?

Answer 6

ITP

Question 7

What are important disorders to check for before settling on ITP?

Answer 7

Lupus, Medications, Lymphoma, HepC, HIV

Question 8

Which thrombocytopenia is considered a “diagnosis of exclusion”?

Answer 8

ITP

Question 9

What are the three causes of decreased platelet production?

Answer 9

Leukemia, Immune system disorder, ITP

Question 10

What are the 5 causes of increased platelet destruction?

Answer 10

ITP, TTP HUS, HIT, DIC

Question 11

DIC is a secondary cause of what?

Answer 11

Sepsis, Cancer, Trauma, Pregnancy

Question 12

Which factors are deficient in the Hemophilias?

Answer 12

Factor XIII in A

Factor IX in B