Hematology 🩸

Question 1

Screen for anemia in preterm child at age
A. 3 months
B. 6 months
C. 12 months
D. 18 months

Answer 1

C. 12 months

Question 2

Age of physiologic anemia […]

Answer 2

3 months (8-12 weeks)
Preterm decline extreme & rapid » 3-6 wk

Question 3

3 months old, low Hb, High MCV
+ café au lait spots + microcephaly
A. Physiologic anemia of infancy
B. IDA
C. Fanconi anemia
D. Transient erythrocytpemia of childhood

Answer 3

C. Fanconi anemia

Question 4

10 months old with anemia, found to have triphalangeal thumb

Answer 4

Diamond blackfan anemia

Question 5

3 mo baby have pallor, recently came from india. He is on breastfeeding
CBC- microcytic anemia 🔻MCV 🔻MCH
A. IDA
B. Thalassemia trait
C. Sickle cell
D. G6PD

Answer 5

B. Thalassemia trait
Age (3mo) doesn’t go with IDA

Question 6

[…] decrease incidence of acute chest syndrome, strike & VOC in SCD
By 🔺 HbF and 🔻HbS

Answer 6

Hydroxyurea

Question 7

[…] disease associated with hyposplenism

Answer 7

SCD

Question 8

Which of the following suggestive of thalassemia rather than IDA?
A. Microcytic anemia
B. High RDW
C. Low serum iron
D. Low TIBC
E. Increase HbA2

Answer 8

E. Increase HbA2

Question 9

Hydrops fetalis associated with […]

Answer 9

alpha thalassemia

Question 10

Which disease can be cured by splenectomy?
A. Sickle cell
B. Thalassemia
C. Spherocytosis
D. G6PD

Answer 10

C. Spherocytosis

Question 11

Child present with pallor & jaundice. His father & grandfa are both known to have chronic hemolysis and underwent gall bladder removal
Best test for diagnosis:
A. Hb electrophoresis
B. Sickle cell test
C. Coombs test
D. Osmotic fragility test

Answer 11

D. Osmotic fragility test

Autosomal dominant pattern = Spherocytosis
Gold standard Dx: EMA test
Tx: splenectomy (curative)

Question 12

12 hrs baby boy found to have jaundice that increased at 36 hrs. Next step:
A. Osmotic fragility test
B. G6PD
C. Electrophoresis
D. Sickle test

Answer 12

A. Osmotic fragility test

Hemolytic disease that cause neonatal jaundice:
☑️G6PD
☑️Spherocytosis
☑️Pyruvate kinase deficiency

Question 13

Avoid in G6PD:
A. Aspirin
B. Paracetamol
C. Allopurinol
D. Ibuprofen

Answer 13

A. Aspirin

Question 14

Avoid in Familial mediterranean fever:
A. Macrolide
B. Amoxicillin
C. Aspirin
D. Cefuroxime

Answer 14

A. Macrolide
🚫Statin
🚫Verapamil
» interfere with cytochrome metabolize colchicine (DOC)

Question 15

Coagulation profile

Answer 15

Bleeding time » platelet
PT » extrinsic pathway
PTT » intrinsic pathway

Question 16

Prolonged PTT

Answer 16

APS
Hemophilia
Heparin

Question 17

Prolonged PT

Answer 17

Liver disease
Factor 7 deficiency
Warfarin

Question 18

Prolonged PT & PTT

Answer 18

Liver disease
Vit K deficiency
Factor 1,2,5,10 deficiency (common pathway)

Question 19

Coagulopathies
🔹vWD
🔹Hemophilia
🔹Vit K deficiency
🔹DIC
🔹ITP

Answer 19

🔹vWD : 🔺BT & PTT
🔹Hemophilia : 🔺PTT
🔹Vit K deficiency : 🔺 PT
🔹DIC : 🔺BT 🔺PTT 🔺PT
🔹ITP : thrombocytopenia

Question 20

Baby delivered at home and present to ER with hematemesis
Which factor might be deficient?
A. 11
B. 8
C. 12
D. 10

Answer 20

D. 10
Newborn = vitamin K ‼️
2, 7, 9, 10

Question 21

Baby delivered, after cutting the umbilical cord he bled profusely
Which factor affected?
A. 1
B. 10
C. 12
D. 13

Answer 21

13
Factor 13 deficiency = heavy bleeding from umbilical cord

Question 22

Recurrent epistaxis, PTT prolonged

Answer 22

Hemophilia

Question 23

Recurrent epistaxis, PTT & BT prolonged

Answer 23

vWD

Question 24

Tumor lysis syndrome electrolyte abnormality:

Answer 24

🔺Hyperuricemia
🔺K
🔺PO4
🔻Ca

Question 25

Child with arthritis, fever, epistaxis, gingival bleeding, lab: 🔻plt 🔻Hb
What investigation you need to order?
A. Bone marrow aspiration
B. Electrophoresis
C. Anti ds-DNA
D. ANA

Answer 25

A. Bone marrow aspiration
“Leukemia”

Question 26

In Down syndrome which leukemia type is most common?
A. ALL
B. AML
C. CML
D. CLL

Answer 26

A. ALL
>5 yrs = ALL
<5 yrs = AML

Question 27

African teen with jaw mass histopathotolgy show starry sky appearance (case of burkitt’s lymphoma). Whats pathophysio?
A. Over-expression of c-myc
B. Over-expression of n-myc
C. Over-expression of Fab
D. Over-expression of k-ras

Answer 27

A. Over-expression of c-myc

Question 28

BCL BCR gene associated with:
A. ALL
B. CLL
C. CML
D. AML

Answer 28

C. CML
Philadelphia chromosome t(9;22)

Question 29

5 yo unwell with LL ecchymosis, +ve CD10 (CALLA). Dx: […]

Answer 29

ALL