Hematology 🩸 Flashcards
Screen for anemia in preterm child at age
A. 3 months
B. 6 months
C. 12 months
D. 18 months
C. 12 months
Age of physiologic anemia […]
3 months (8-12 weeks)
Preterm decline extreme & rapid » 3-6 wk
3 months old, low Hb, High MCV
+ café au lait spots + microcephaly
A. Physiologic anemia of infancy
B. IDA
C. Fanconi anemia
D. Transient erythrocytpemia of childhood
C. Fanconi anemia
10 months old with anemia, found to have triphalangeal thumb
Diamond blackfan anemia
3 mo baby have pallor, recently came from india. He is on breastfeeding
CBC- microcytic anemia 🔻MCV 🔻MCH
A. IDA
B. Thalassemia trait
C. Sickle cell
D. G6PD
B. Thalassemia trait
Age (3mo) doesn’t go with IDA
[…] decrease incidence of acute chest syndrome, strike & VOC in SCD
By 🔺 HbF and 🔻HbS
Hydroxyurea
[…] disease associated with hyposplenism
SCD
Which of the following suggestive of thalassemia rather than IDA?
A. Microcytic anemia
B. High RDW
C. Low serum iron
D. Low TIBC
E. Increase HbA2
E. Increase HbA2
Hydrops fetalis associated with […]
alpha thalassemia
Which disease can be cured by splenectomy?
A. Sickle cell
B. Thalassemia
C. Spherocytosis
D. G6PD
C. Spherocytosis
Child present with pallor & jaundice. His father & grandfa are both known to have chronic hemolysis and underwent gall bladder removal
Best test for diagnosis:
A. Hb electrophoresis
B. Sickle cell test
C. Coombs test
D. Osmotic fragility test
D. Osmotic fragility test
Autosomal dominant pattern = Spherocytosis
Gold standard Dx: EMA test
Tx: splenectomy (curative)
12 hrs baby boy found to have jaundice that increased at 36 hrs. Next step:
A. Osmotic fragility test
B. G6PD
C. Electrophoresis
D. Sickle test
A. Osmotic fragility test
Hemolytic disease that cause neonatal jaundice:
☑️G6PD
☑️Spherocytosis
☑️Pyruvate kinase deficiency
Avoid in G6PD:
A. Aspirin
B. Paracetamol
C. Allopurinol
D. Ibuprofen
A. Aspirin
Avoid in Familial mediterranean fever:
A. Macrolide
B. Amoxicillin
C. Aspirin
D. Cefuroxime
A. Macrolide
🚫Statin
🚫Verapamil
» interfere with cytochrome metabolize colchicine (DOC)
Coagulation profile
Bleeding time » platelet
PT » extrinsic pathway
PTT » intrinsic pathway
Prolonged PTT
APS
Hemophilia
Heparin
Prolonged PT
Liver disease
Factor 7 deficiency
Warfarin
Prolonged PT & PTT
Liver disease
Vit K deficiency
Factor 1,2,5,10 deficiency (common pathway)
Coagulopathies
🔹vWD
🔹Hemophilia
🔹Vit K deficiency
🔹DIC
🔹ITP
🔹vWD : 🔺BT & PTT
🔹Hemophilia : 🔺PTT
🔹Vit K deficiency : 🔺 PT
🔹DIC : 🔺BT 🔺PTT 🔺PT
🔹ITP : thrombocytopenia
Baby delivered at home and present to ER with hematemesis
Which factor might be deficient?
A. 11
B. 8
C. 12
D. 10
D. 10
Newborn = vitamin K ‼️
2, 7, 9, 10
Baby delivered, after cutting the umbilical cord he bled profusely
Which factor affected?
A. 1
B. 10
C. 12
D. 13
13
Factor 13 deficiency = heavy bleeding from umbilical cord
Recurrent epistaxis, PTT prolonged
Hemophilia
Recurrent epistaxis, PTT & BT prolonged
vWD
Tumor lysis syndrome electrolyte abnormality:
🔺Hyperuricemia
🔺K
🔺PO4
🔻Ca
Child with arthritis, fever, epistaxis, gingival bleeding, lab: 🔻plt 🔻Hb
What investigation you need to order?
A. Bone marrow aspiration
B. Electrophoresis
C. Anti ds-DNA
D. ANA
A. Bone marrow aspiration
“Leukemia”
In Down syndrome which leukemia type is most common?
A. ALL
B. AML
C. CML
D. CLL
A. ALL
>5 yrs = ALL
<5 yrs = AML
African teen with jaw mass histopathotolgy show starry sky appearance (case of burkitt’s lymphoma). Whats pathophysio?
A. Over-expression of c-myc
B. Over-expression of n-myc
C. Over-expression of Fab
D. Over-expression of k-ras
A. Over-expression of c-myc
BCL BCR gene associated with:
A. ALL
B. CLL
C. CML
D. AML
C. CML
Philadelphia chromosome t(9;22)
5 yo unwell with LL ecchymosis, +ve CD10 (CALLA). Dx: […]
ALL
