Hematology

Question 1

Examples of LMWH drugs

Answer 1

Enoxaparin
Dalteparin
Tinzaparin

Question 2

Direct oral anticoagulants

Answer 2

Direct factorsXa inhibitors(rivaroxaban,apixaban,
edoxaban)

Direct, thrombin inhibitor’s( lepiudin,argatroban , dabigatran)

Question 3

D dimer

Answer 3

D-dimer is a protein fragment (small piece) that’s made when a blood clot dissolves in your body.

Question 4

Causes of DIC

Answer 4

Obstetrical emergencies
Sepsis
Leukemia (specially promyelocytic leukemia)
Rattlesnake bites

Question 5

DIC on lab

Answer 5

• Elevated PT /PTT /Thrombin time
• Low platelets
Consumption of platelets in thrombi
• Low fibrinogen (consumption)
- Microangiopathic hemolytic anemia
• Low RBC (anemia)
• Schistocytes on blood smear
Elevated D-dimer

Question 6

Rx of DIC

Answer 6

Fresh, frozen plasma
Cryoprecipitate
Treat the underlying disorder

Question 7

B thalassemia minor features

Answer 7

• Mildest form of disease
• Usuallv asvmptomatic with increased RBC count
• Microcytic, hypochromic RBCs and target cells on blood

Hemoglobin electrophoresis
• Slightly decreased HbA(2(alpha, beta))
• Increased HbA2 ( 2(alpha, gama))to 5% (normal 2.5%)
• Increased HbF to 2% (normal 1%)