Hematology

Question 1

Blood smear in CLL

Answer 1

Monoclonal lymphocytes
Cd5 positive
Smudge/busket cell

Question 2

Blood smear in CML

Answer 2

Immature granulocytes
Absolute basophilia/eosinophilia

Question 3

Blood smear in MM

Answer 3

Myelobladts
Aure rods
Rouleaux formation

Question 4

Facs in follicular lymphoma

Answer 4

Cd 20
CD 19
CD 10
BCL 6

T 14-18
ABNORMAL BCL 2 PROTEIN
POSITIVE FREE LIGH CHAIN

Question 5

Mechanism of anemia in MM

Answer 5

• Bone marrow invasion of B cells
• Cytotoxins inhibiting heamatopoiesis
• decreased EPO
• heamolysis

Question 6

Drugs that induce hemolysis in G6PD deficiency

Answer 6

sulfa drugs (Trimethoprim-sulfamethaxazole)
Rasburikace (urate oxidase)
Primiquine (anti-malaria)
Phenazupyridine
methenl blue

Question 7

Bone Marrow in Aplastic anemia

Answer 7

Hypocellularity
Lipid Tissue

Question 8

Treatment of Aplastic anemia

Answer 8

• Bone marrow transplantation
• if not possible (no match or elderly): Cyclosporine+ Anti-thymocyte globulin

Question 9

Treatment of polycythemia Vera

Answer 9

• phlebotomy (target hematocrit <45% in men, <42% in women)
• in case of Symptomatic thrombocytosis - erythromyalgia/ ocular migrane : hydroxyurea- anagrelide (phosfodysterase inhibitor)
• Rouxtinib- symptomatic splenomegaly (abdominal pain, early satiety), pruritus, systemic symptoms