Hematological malignancies Flashcards
A 67 year old lady is found to have an Hb of 18.9g/dL. Her erythropoeitin level is markedly raised. Which of the following is the most likely diagnosis?
A) COPD
B) Eisenmenger’s syndrome
C) Polycythaemia vera
D) Renal cell carcinoma
E) Nepalese woman living at high altitude
E
A 66 year old man has a CBC done whilst being tested for hypercholesterolaemia and was found to have a WBC of 15.4x109/L with the rest of the count otherwise normal. The most likely diagnosis is:
A) Infectious mononucleosis
B) CMV infection
C) ALL
D) Pertussis
E. Chronic lymphocytic leukaemia
E
Which ONE of these is the most likely clinical presentation of a child with acute lymphoblastic leukaemia?
a) A 6 month history of fatigue and repeated upper respiratory tract infection
b) Poor appetite and abdominal pain resulting from swollen spleen
c) Swollen gums in the mouth
d) Recent history of bruising and tiredness
e) None- incidental finding
*Anaemia and thrombocytopenia common
D
Which ONE of these is NOT TRUE regarding the Reed-Sternberg cell in Hodgkin’s lymphoma?
a) It is thought to be of B cell lineage‐
b) It is multinucleate
c) It represents the majority of cells in a lymph node of Hodgkin’s lymphoma
d) It usually expresses CD15 and CD30
e) Their absence has a high negative predictive value
*Near-pathogonomic but in the minority of cells
C
A 59 ear old man receiving chemotherapy for Non Hodgkin’s Lymphoma develops painful haematuria. Which of the following is the most likely cause of his symptoms?
A) Rituximab
B) Cyclophosphamide
C) Adriamycin (doxorubicin/ hydroxydaunarubicin)
D) Vincristine (oncovin)
E) Prednisolone
B
A 63 year old woman is about to commence chemotherapy for treatment of MM. Which of the following medications should she be started on prior to chemotherapy?
A) Colchicine
B) Dexamethasone
C) Diclofenac
D) Allopurinol
E) Hydroxychloroquine
D
Which one of the following is not consistent with a diagnosis of MGUS?
A) normal urinalysis
B) normal renal function
C) 20% plasma cells in bone marrow
D) Normochromic, normocytic anaemia with Rouleaux formations
E) Absence of lytic bone lesions
C
A patient has a sharp M band on serum electrophoresis. Which of the following is least consistent with this result?
A) IgG MM
B) Waldenstrom’ macroglobulinaemia
C) AA amyloidosis
D) MGUS
E) CLL
C
Some of the most common symptoms associated with myelodysplastic syndromes are:
A) ThrombocytopeniaB) AnemiaC) NeutropeniaD) All of the above
D
Stem-cell transplantation is currently the only treatment option with the potential to cure myelodysplastic syndromes
True
Dalse
A
All of the following are included in the chronic myeloproliferative disorders exceptA) acute myeloid leukemia.B) chronic myelogenous leukemia.C) polycythemia vera.D) essential thrombocythemia.
A
What clinical feature is more often associated with essential thrombocytosis than with the other chronic myeloproliferative disorders?
A) splenomegalyB) bleeding and thrombosisC) fatigueD) infections
B
The Janus kinase (JAK)mutation is seen in more than 90% of cases of what disease?A) chronic myelogenous leukemiaB) primary myelofibrosisC) plasma cell myelomaD) polycythemia vera
D
Exposure to high levels of benzene in the workplace can cause leukemia.
A)True
B)False
A
Acute myeloid leukemia (AML) is a life-threatening disorder in which certain blood cells become cancerous and rapidly replace normal cells in the bone marrow. As normal blood cells are replaced by cancerous cells, people with AML become anemic from too few red blood cells. They develop infections easily because there are too few white blood cells to fight infections, and their blood does not clot well because of too few platelets. Which of the following additional symptoms of AML may be caused by having too few white blood cells?
A) Bruising easily
B) Having frequent nosebleeds
C) Running a fever
D) Tiring quickly
C
