Hemato/blood Physio Pt 2/2 (Hemostasis and Anti-coag) Flashcards
What are blood clots consist of?
Explain the process of primary hemostasis.
Note: primary hemostasis = platelet plug formation -> 3 main steps!
Does thrombin play a role in platelet adhesion, activation or aggregation?
Which phase: A, A, or A, does aspirin disturb (in pri hemostasis)?
Explain the process of secondary hemostasis. (rmb to incl the requirements)!
Note: primary hemostasis = blood clot formation
Which clotting factors need which Vit for production?
Where are clotting factors made, and what (material) are they?
Any exceptions?
Liver; plasma proteins
except:
Ca2+, ion from diet mostly
Tissue factor, from damaged endothelial cells
Why is thrombin said to be part of positive feedback loop in coagulation cascade?
What factors do:
(i) thrombin activate
(ii) anti-thrombin deactivate?
What are the 3 parts to anticoagulation? Explain each part.
Hint:
1. NP
2. ATA
3. tPA+fibrin
- NP [platelet plug prevention]
- ATA [blood clot prev]
- tPA+fibrin [blood clot removal]
What does serum D-dimer levels (high) indicate
What increases the risk of thrombosis?
Virchow’s Triad HE’S
- what are the sub-factors?