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HISTO Block B > Hemapoiesis Review > Flashcards

Hemapoiesis Review Flashcards

1
Q

Give the time period for liver phase.

A

1-9 months

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2
Q

Name two adult loci for blood development

A

Myeloid tissue in bone, lymphoid tissue

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3
Q

What is the characteristic shape of megakaryocyte?

A

Lobed, polyploidy nucleus (32-64N)

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4
Q

Thromopoiesis
Give 5 stage of developmental sequence.
Where does it reside permanently? (it = megakaryocytes)
(nucleus)

A

MEP -> CFU-Meg -> Megakaryoblast -> Megakaryocyte -> Platelets
Bone marrow

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5
Q

Give the time period for adult phase.

A

4+ months

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6
Q

Give the time period for spleen phase.

A

3-6.5 months

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7
Q

What cells do megakaryocytes give rise to?

A

platelets

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8
Q

What characteristic feature do you see on megakaryocytes’ cytoplasm?

A

Demarcation channels

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9
Q

Give the time period for Yolk-Sac phase.

A

Conception – 3 months

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10
Q

What kind of cells forms blood islands in wall of yolk sac seeding numerous CFUs?

A

Embryonic mesoderm (mesenchymes)

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11
Q

What does monophyletic theory hold?

A

All blood cells arise from a huge common stem cell called HSC (hemopoietic stem cell)

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12
Q

Iron in hemoglobin is retrieved by spleen as what?

A

Ferritin

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13
Q

Heme is secreted as what by gall bladder.

A

bilirubin

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14
Q

Give 4 stages of monocyte development.

A

CFU-GM -> Promonocyte -> Monocyte -> Tissue-specific macrophages

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15
Q

Give 4 general features of erythropoiesis.

A

Decrease in cell size, increase in heterochromatin, progressive loss of cytoplasmic organelles,
accumulation of cytoplasmic hemoglobin

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16
Q

At what stage does mitosis stop?

A

Metamyelocyte (first non-mitotic stage)

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17
Q

At what stage do you start to not see nucleoli?

A

Myelocyte

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18
Q

Give 4 different types of macrophages!

A

Lung – alveolar macrophages, Liver – Kupffer cells, Bone – osteoclasts, Loose CT – tissue macrophages

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19
Q

Colony forming unit looks like what?

A

Small lymphocyte

20
Q

What morphologically most resembles a small lymphocyte?

A

Pluripotential HSC

21
Q

CFU’s potency increases or decreases as cells become differentiated?

A

decreases

22
Q

Colony forming unit is derived from what?

A

Mesenchymal reticular tissue

23
Q

What is the difference between progenitor and precursor cells?

A

Progenitor – unipotential and self-renewing

Precursor – unipotential, but not self-renewing

24
Q

Where is the site of normal adult hemopoiesis?

A

Medullary cavity of Bone

25
Q

Which marrow is hemopoetically active?

A

Red

26
Q

Adventitial cells manufacture what?

A

Reticular fibers

27
Q

What cells are most predominant cell types undergoing development in marrow?

A

Neutrophils (RBC 2nd)

28
Q

Which marrow has reduced hemopoietic activity?

A

Yellow

29
Q

Describe the common changes that occur during differentiation into mature cell.

A

Decrease in two things, increase in six things
Cell size and cytoplasmic basophilia (aka azure granule content)
Nuclear heterochromatin, specific granule content, deformability, adhesiveness, phagocytic activity, and mobility

30
Q

At which stage does differentiation occur?

A

Myelocyte

31
Q

Describe what Myeloblast’s cytoplasm looks like.

A

Increasing eosinophilia, decline in azure granules, well-developed golgi

32
Q

What kind of granules does promyelocyte have?

A

Only azure granules

33
Q

At what stage do you identify specific granulocyte lineage?

A

(has specific granules) Myelocyte

34
Q

Why is granulocyte’s concentration higher in marrow than erythrocyte’s?

A

Shorter life spans

35
Q

Lymphoblasts are only cell bodies that develop both in what two tissues?

A

Lymphoid and myeloid tissues

36
Q

What is the other name for polychromatophilic erythrocyte?

A

Reticulocyte

37
Q

What characteristic feature does orthochromatophilic erythroblast have?

A

(name 2) Acidophilic cytoplasm, pyknotic nucleus, and Howell-Jolly body

38
Q

Give 3 stages of lymphopoiesis.

A

CFU-L -> lymphoblast -> lymphocytes

39
Q

What other cell does erythrocyte share their progenitor with?

A

Platelet

40
Q

What happens when you have hypoxia? (hint: induces what)

A

erythropoiesis

41
Q

How is erythropoiesis regulated?

A

Feedback loop

42
Q

Give 8 stages of erythropoiesis.

A

MEP -> CFU -> proerythroblast -> basophilic erythroblast -> polychromatophilic erythroblast ->
orthochromatophilic erythroblast -> reticulocyte -> mature erythrocyte

43
Q

What is the different between promyelocyte and proerythroblast?

A

Presence of granules

44
Q

What does basophilic erythroblast remind you of?

A

Robin’s egg

45
Q

During erythropoiesis, when does cell not undergo mitosis?

A

Orthochromatophilic erythroblast stage

46
Q

What characteristic feature does polychromatophilic erythroblast have?

A

Checkerboard pattern, shifting from blue to pink

47
Q

At what stage do you not see a nucleus?

A

Poly

HISTO Block B (3 decks)

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