HEMA LEC WEEK 14 Flashcards
High WBC count
leukocytosis
what is the absolute leukocyte count of leukocytosis
11.0x10^9/L
what is the absolute leukocyte count of leukopenia
<3.0x10^9/L
other quantitative disorders with absolute leukocyte count of <3.0
neutropenia
granulocytopenia
lymphopenia
pancytopenia
what is the absolute neutrophil count of neutrophilia
> 7.0-8.0
pathologic causes of neutrophilia
- infection
- malignancy
- inflammation
- metabolic disorders
- drugs
specific fungal that causes neutrophilia
actinomycosis
specific viral that causes neutrophilia
varicella
variola
rabies
herpes zoster
malignancy
neoplastic growth
abnormal growth of tissue
neoplastic growth
examples of inflammation that causes neutrophilia
serosal
visceral
blood cell destruction
post traumatic
thermal injury
chemicals or drugs
what are the common metabolic disorders that causes neutrophilia
diabetes
renal dysfunction
liver disease
common drugs that causes neutrophilia
corticosteroids
lithium
examples of physical stimuli that causes neutrophilia
exercise
excessive temp changes
nausea
vomiting
pregnancy
labor
emotional stimuli that causes neutrophilia
rage
panic
stress
most common type of leukopenis
neutropenia
what is the absolute neutrophil count of neutropenia
<1.76 - 1.8
extreme neutropenia
agranulocytosis
absolute neutrophil count od agranulocytosis
<0.5
what are the causes of neutropenia
decreased neutrophil prod
inherited stem cell disorders
acquired stem cell disorders
increased neutrophil destruction
infections
immune reactions
drug induces
increased sequestration
pseudoneutropenia
what is an example of inherited stem cell disorder that causes neutropenia
fanconi syndrome
what are the common examples of acquired stem cell disorders that causes neutropenia
chemical toxicity
marrow replacemsnt
nutritional deficiencies
cytotoxic drugs
example of bacterial infections that causes neutropenia
bacterial
- typhoid
- paratyphoid
- brucellosis
examples of viral infections that causes neutropenis
measles
yellow fever
hepatitis
mononucleosis
rubella
immune reactions that causes neutropenia
neonatal isoimmune neutropenia (maternal IgG)
autoimmue
common examples of immune reaction that causes neutropenia
lupus
felty’s syndrome
common examples of drug induced that causes neutropenia
amidopyrine
cephalosphorins
associated with splenic enlargement and increased margination
increased sequestration
