Hem Onc Rotation chemo pt 1

Question 1

7+3
tx for what?
what meds when?

Answer 1

newly diagnosed AML (<65 yrs) induction tx
Ara-C aka Cytarabine (days 1-7)
Daunorubicin (days 1-3)

Question 2

HiDAC = __
tx for what?
what meds when?

Answer 2

AML in remission
HiDAC = high dose cytarabine consolidation
Cytarabine 3000mg/m2 over 3 hrs q 12 hrs every other day for 6 doses

Question 3

common side fx of HiDAC, what’s done about ‘em? (4)

Answer 3

Uveitis/Conjunctivitis - steroid eye drops administered during & 48 hrs after
N/v - zofran + dexamethasone
Cerebellar toxicity - neuro exam (finger to nose coordination test)
Rash, fever, flushing during infusion - slow down infusion, give hydrocortisone 100mg + Benedryl, premedicate future infusions

Question 4

MEC = __
tx for what?
what meds when?

Answer 4

AML - refractory/relapsed
Mitoxantrone 8mg/m2 daily x 6 doses
Etopaside - 80mg/m2 daily x 6 doses
Ara-C - 1 gram/m2/day x 6 doses

Question 5

Mitoxantrone (of MEC) side fx (3)

what must you know prior to initiating?

Answer 5

N/V: zofran & dexamethasone
Cardiac toxicity: Must know EF prior to initiating
Turns urine & secretions blue x 24 hrs

Question 6

Side fx of Etoposide

Answer 6

usually well tolerated