Hem Onc Review pt1

Question 1

maturation of a neutrophil steps

Answer 1

Premyeloblast -> Premyelocyte -> Myelocyte -> Metamyelocyte -> Band -> Mature Neutrophil

Question 2

Bone marrow cellularity calculation

Answer 2

100-age

Question 3

B cell development

Answer 3

common lymphoid progenitor cell -> Pro-B cell -> Pre-B cell (via interleukein 7) -> terminal differentiation in peripheral lymph nodes into circ’n

Question 4

How to calculate Reticulocyte index.

What does it mean?

Answer 4

Retic count x (hct/idealhct) x 0.5

> 2% suggests blood loss or hemolysis anemia
2% suggests bone marrow production defect

Question 5

RDW in fe defic anemia vs thalassemia

Answer 5

higher in fe defic

lower in thalassemia

Question 6

When iron is absorbged in duodenum/jejunum, where does it go when it’s in plasma?

Answer 6

binds to Transferrin -> to bone marrow cells to make hgb.

Question 7

Transferrin saturation means

Answer 7

available binding sites for iron in the blood

Question 8

transferrin will decrease due to: (3)

Answer 8

liver disease, malnutrition, inflammation

Question 9

in Fe defic anemia, what will bone marrow aspiration show?

Answer 9

Complete absence of intracellular iron deposits

Question 10

Dx and tx of fe dfic anemia

Answer 10

Dx: Low ferritin (<12)
Tx: Fereheme (parenteral iron)

Question 11

MCV >100 with anisocytosis and poikilocytosis

Answer 11

Megaloblastic anemia

Question 12

What can inactivate B12 to lead to defic?

Answer 12

nitrous oxide

Question 13

Tx of B12 defic, (what route of admin)?

Answer 13

B12 IM

Question 14

More reliable test to dx folic acid defic

Answer 14

RBC folic acid

Question 15

Heinz-body is found in

Answer 15

G6PD defic