Helper CD4+ T cells

Question 1

Th1 polarized by?

Answer 1

IL-12, IL-18, IFN-gamma

Question 2

Th2 polarized by?

Answer 2

IL-4

Question 3

Th17 polarized by?

Answer 3

IL-1, IL-6, IL-23, TGF-beta

Question 4

Treg polarized by?

Answer 4

IL-2, TGF-beta

Question 5

Tfh polarized by?

Answer 5

IL-6, IL-21

Question 6

Th1 effector cytokines made?

Answer 6

INF-gamma, TNF-beta

Question 7

Th2 effector cytokines made?

Answer 7

IL-4, IL-5, IL-13

Question 8

Th17 effector cytokines made?

Answer 8

IL-17, IL-22

Question 9

Tfh effector cytokines made?

Answer 9

IL-4, IL-21

Question 10

Treg effector cytokines made?

Answer 10

IL-10, TGF-beta

Question 11

Th1 master transcriptional regulator?

Answer 11

T-bet

Question 12

Th2 master transcriptional regulator?

Answer 12

GATA-3

Question 13

Th17 master transcriptional regulator?

Answer 13

RORyt

Question 14

Tfh master transcriptional regulator?

Answer 14

Bcl-6

Question 15

Treg master transcriptional regulator?

Answer 15

FOX-P3

Question 16

Th1 main functions

Answer 16

• Inflammation
• Cell mediated immunity
• IFNy polarizes macrophages into M1, activates, and attracts them.
• T cell recognizes. Macrophage removes

Question 17

Th2 main functions

Answer 17

• Polarized macrophages into M2 by IL-4 and IL-13.
• IL-4 and IL-5 attract eosinophils.
• Allergic and anti-helminth responses–> m2 response and stimulates switch to IgE

Question 18

Th17 main functions

Answer 18

• IL-17 and IL-22 attract and activate many inflammatory cells
• M1 response
• Maintaining integrity of mucosal surface

Question 19

Tfh main functions

Answer 19

• B cell help in germinal centers

- Help them become activated and direct B cells to undergo class-switching

Question 20

Treg main functions

Answer 20

Suppresses Th1, Th2, Th17, Tfh by contact and soluble factors (TGF-beta, IL-10)