heart/heart problems Flashcards
what are the characteristics of the arteries =
-narrow lumen
-thicker walls
-more collagen, smooth muscle and elastic fibres
-no valves
what are the characteristics of the veins?
-wide lumen
-thinner walls
-less collagen, less smooth muscle, fewer elastic fibers
-valves
what does a circulatory system need?
a pump, blood vessels and transport medium
what is the function of valves?
prevent backflow
what are the three stages of the heart cycle?
atrial systole, ventricular systole and diastole
what happens in the atrial systole?
The blood flows into the atria with low pressure from the pulmonary veins and the vena cava. The pressure increases and pushes against the atrioventricular valves.
The atria contract (atrial systole) forcing the blood to flow into the ventricles through the tricuspid (dx) or bicuspid (sx)
what happens in the ventricular systole?
the ventricles contract from the base of the heart upwards, pushing the blood through the semilunar valves in the pulmonary arteries and aorta. The pressure afterwards closes the valves preventing blood flow backwards
what happens in the diastole?
The atria and ventricles relax. The low pressure in the atria helps draw blood into the heart from the veins
What happens in atherosclerosis?
- the endothelium breaks triggering an inflammatory response
- white blood cells arrive and move into the artery wall where they deposit fats like cholesterol
- a fatty deposit builds up called atheroma
- calcium salts and fibrous tissue also build up on the site creating a hard plaque on the wall
as a result, the wall loses elasticity and the plaque makes the lumen narrower
what does atherosclerosis lead to?
heart disease like heart attack (Myocardial infarction) and strokes
what does the endothelium do?
thin layer of cells, separates the blood that flows in the artery from the muscle wall
what can cause the endothelium to break?
High blood pressure or toxins from cigarette smoke in the bloodstream
process of blood clotting
-platelets come into contact with damaged cells and change shape from flattened to spheres with long thin projections
-they are now able to stick to each other and the cell wall creating a platelet plug, in addition to releasing substances
-contact of blood with collagen triggers a cascade of changes
-thromboplastin is released from platelets and tissue
- this + calcium ions + vitamin K change prothrombin to thrombin
- soluble fibrinogen into insoluble fibrin
-clot
what is chest pain called ?
Angina, generally experienced when the heart is working harder and needs to respire more. It’s forced to respire anaerobically and this triggers pain
What does it mean for a heart muscle to be ischaemic ?
It doesn’t receive any blood
What causes a stroke ?
A blood clot that stops the blood supply to the brain
How do we define risk ?
The probability of an occurrence of some unwanted event to happen
What is a cohort study ?
Case control studies follow a large group of people overtime without a disease to see who develops it. Their exposure to risk factors is also documented. PROSPECTIVE
What is a case-control study
A group of people with a disease is compared with a group of individuals that do not have it. RETROSPECTIVE because look at histories of exposure to risk factors, compare and look for correlations