Heart Failure Flashcards
T/F patients with heart failure all have volume overload
FALSE
why the term “heart failure” is actually preferred over CHF
volume coming into ventricles (end diastolic pressure)
preload
resistance - left ventricle must overcome to circulate load
afterload
percent of left ventricular blood ejected during each systolic contraction
ejection fraction (EF)
What is a normal EF?
60%
How is EF calculated?
stroke volume/end-diastolic volume
HFrEF
systolic dysfunction
heart failure with reduced ejection fraction
Disease that might lead to HFrEF
cardiomyopathies, CAD, valve diseases, arrhythmias
HFpEF
diastolic dysfunction
heart failure with preserved ejection fraction
Problem with HFpEF is _______ and problem with HFrEF is _________
1) filling (diastolic dysfn)
2) ejection (systolic dysfn)
Disease that might lead to HFpEF
chronic hypertension, aortic stenosis, cardiomyopathies (hypertrophic or restrictive)
What is the Frank-Starling mechanism?
the ability of the heart to change its force of contraction and therefore stroke volume in response to changes in venous return
(i.e. incr. venous return to the heart –> incr. SV)
Symptoms of HF
FACES
Fatigue Activity decrease Cough (esp. supine) Edema Shortness of breath
What is the DIET approach to pt. w/ HF?
Diagnose
Initiate (drugs)
Educate (diet, lifestyle)
Titrate (adjust drugs)
What is EF in HFrEF?
= 40%
What is EF in HFpEF?
> /= 50%
Which type of HF has actually been studied in clinical trials?
Only HFrEF (systolic HF)
To date, efficacious therapies have not been identified for HFpEF (diastolic HF)
**HFpEF is a dx of exclusion
Stage A HF (ACC-AHA Classification)
High risk for HF, no SHD
HTN, CAD, DM, obesity, metabolic syndrome
Stage B HF (ACC-AHA Classification)
Asymptomatic HF, +SHD
previous MI, LVH, or low EF, asx valvular dz
Stage C HF (ACC-AHA Classification)
Symptomatic HF, +SHD
SOB, fatigue, reduced exercise tolerance
Stage D HF (ACC-AHA Classification)
Refractory end-stage HF, +SHD
sx at rest despite maximal medical therapy; recurrent hospitalizations
When would you use diuretics in HF?
symptomatic benefit in pt. w/ current or prior sx of HF and reduced LVEF who have evidence of fluid retention
should use used along with salt restriction
(in general should not be only therapy in stage C)
What is a ceiling dose?
eventually, if you keep pushing the dose, you don’t get a greater benefit (this is when you would add another drug)
**Pt. with HF need higher doses of diuretics to get same response, and have diminished responses to ceiling doses
T/F, you cannot use thiazide and loop diuretics in combination
FALSE
esp. in pt. with HF that have diuretics resistance to loops, you may need to a thiazide in combo
What monitoring should be done in pt. on diuretics?
electrolytes (esp. potassium)
loop diuretics are more powerful than thiazides and must be used with caution to avoid dehydration
What is the key point to remember when tx pt. with diuretics?
SODIUM RESTRICTION!
if they aren’t restricting sodium, the diuretics may not work b/c water will follow sodium
Nitroglycerine class
Nitrate - vasodilator
Nitroglycerine MOA (HF)
decreases preload
stimulates NO
Nitroglycerine indications (HF)
warm and wet acute decompensated HF (ADHF), ACS
Nitroglycerine adverse effects
hypotension, reflex tachycardia, HA, tachyphylaxis
Nitroprusside class
direct vasodilator
Nitroprusside MOA
decreases preload and afterload
stimulates NO
Nitroprusside indications
warm and wet acute decompensated HF (ADHF), alternative to inotropes in cold and wet ADHF
Nitroprusside adverse effects
hypotension or cyanide or thiocyanate toxicity
Nesiritide class
vasodilator, cardiac glycoside