Fundamentals Flashcards
What drugs do to the body
Pharmacodynamics
What the body does to drugs and how fast it does it (absorption, distribution, metabolism, excretion)
Pharmacokinetics
absorption and distribution of drugs is determined by:
1) Drug molecular size
2) Drug solubility
3) Conditions at site of tissues to be penetrated by drug (e.g. inflamm.)
The ________ portion of the membrane is the most difficult portion for a drug to penetrate
lipid
**Drugs that are lipid soluble (non-polar) are able to penetrate membranes more rapidly than those that are polar
Drugs that activate receptors
agonists
Drugs that block receptors
antagonists
dose required to produce minimum response
potency
maximum magnitude of response
efficacy
margin of safety
difference between toxic and effective dose
therapeutic index
ratio of toxic and effective dose (toxic divided by effective)
duration of action
amount of time that drug acts
half-life
time required for 1/2 of drug to be eliminated
Most drug/receptor bonds are ___________ bonds
reversible ionic
Measures of desirable drug actions include:
Efficacy and Potency
When is a drug considered toxic?
When the effective dose and lethal dose are similar