Fundamentals Flashcards

1
Q

What drugs do to the body

A

Pharmacodynamics

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2
Q

What the body does to drugs and how fast it does it (absorption, distribution, metabolism, excretion)

A

Pharmacokinetics

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3
Q

absorption and distribution of drugs is determined by:

A

1) Drug molecular size
2) Drug solubility
3) Conditions at site of tissues to be penetrated by drug (e.g. inflamm.)

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4
Q

The ________ portion of the membrane is the most difficult portion for a drug to penetrate

A

lipid

**Drugs that are lipid soluble (non-polar) are able to penetrate membranes more rapidly than those that are polar

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5
Q

Drugs that activate receptors

A

agonists

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6
Q

Drugs that block receptors

A

antagonists

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7
Q

dose required to produce minimum response

A

potency

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8
Q

maximum magnitude of response

A

efficacy

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9
Q

margin of safety

A

difference between toxic and effective dose

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10
Q

therapeutic index

A

ratio of toxic and effective dose (toxic divided by effective)

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11
Q

duration of action

A

amount of time that drug acts

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12
Q

half-life

A

time required for 1/2 of drug to be eliminated

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13
Q

Most drug/receptor bonds are ___________ bonds

A

reversible ionic

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14
Q

Measures of desirable drug actions include:

A

Efficacy and Potency

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15
Q

When is a drug considered toxic?

A

When the effective dose and lethal dose are similar

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16
Q

3 ways drug actions are ended

A

redistribution, metabolism, excretion

17
Q

the drug is carried away from the site of action, usually by blood flow

A

redistribution

18
Q

the drug is modified to make it less active or more readily excreted

A

metabolism

19
Q

the drug is (or its metabolite) is removed from the body

A

excretion

20
Q

The __________ is the major organ of drug excretion

A

kidney

21
Q

What might happen to a patient with renal pathology?

A

build up of drugs in the body b/c they’re not being excreted - the accumulated drugs can cause toxic effects

22
Q

The ________ is the major organ for metabolizing drugs

A

liver

**this makes it less active and/or more excretable by the kidney

23
Q

first-pass metabolism

A

a swallowed drug goes into the digestive system and then hepatic system before entering circulation to the rest of the body - this great reduces the bioavailability of the drug

24
Q

enterohepatic cycle

A

refers to the cycle of biliary contents, drugs, or other substances from the liver to the bile, and then into the small intestines…ultimately back to the liver and so on. This is often associated with multiple peaks and a longer half-life

25
Q

_________ occurs in lipophilic ER of liver and other cells, and features redox rxn that polarize drug molecule, making them more excretable

A

Phase I Metabolism

26
Q

rate limiting rxn of phase I metabolism require

A

cytochrome P450 enzyme

CYP

27
Q

In __________ endogenous molecules are coupled with parent drugs or metabolites via transferase enzymes, resulting in conjugates that are larger and more excretable

A

Phase II Metabolism

28
Q

Schedule I drugs

A

1) High potential for abuse, severe physical and psychological dependence
2) No accepted medical use
3) Use for research only
4) Not to be prescribed, unsafe for tx

29
Q

Schedule II drugs

A

1) High potential for abuse, severe physical and psychological dependence
2) Acceptable medical uses, w/ restrictions
3) Dispensed by Rx only
4) No refills w/out new written Rx from doc

30
Q

Schedule III drugs

A

1) moderate potential for abuse, high psychological dependence, low physical dependence
2) acceptable medical uses
3) by Rx only; may be refilled 5X in 6 mo. if authorized by doc

31
Q

Schedule IV drugs

A

1) lower potential for abuse than Sched. III; limited psychological and physical dependence
2) Acceptable medical uses
3) by Rx only; may be refilled 5X in 6 mo. if authorized by physician

32
Q

Schedule V drugs

A

1) low potential for abuse
2) acceptable medical uses
3) OTC narcotic drugs, but sold only by registered pharmacists; buyer must be 18 y/o and show ID

33
Q

Schedule VI drugs

A

1) medical marijuana
2) needs Rx

*only some states uses Sched. VI category