Heart & Diabetes Pharmacology III: Drugs and the Heart II Flashcards

1
Q

What are the FOUR classes of Vaughan Williams drugs?

A
  1. Class I - Na+ channel blockers
  2. Class II - β-blockers (target SA node)
  3. Class III - K+ channel blockers
  4. Class IV - Ca2+ channel blockers
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2
Q

What are the effects of Class I drugs on action potentials?

A

Non-nodal
* slows Phase 0 depolarisation
* some alter APD & ERP
* slow conduction velocity

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3
Q

What are the effects of Class II drugs on action potentials?

A

Decrease sinus rate (SA) and conduction through the AV node

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4
Q

What are the effects of Class III drugs on action potentials?

A

Prolong Phase 3 dépolarisation (ERP & APD)
* slow conduction velocity

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5
Q

What are the effects of Class IV drugs on action potentials?

A
  • Main effects on SA & AV nodes
  • Slow Phase 0 depolarisation
  • Decrease sinus rate (SA) and conduction velocity
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