heart defect associations Flashcards

1
Q

heart defect associated with 22q11 syndromes

A

truncus arteriosus, tetralogy of fallot

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2
Q

down syndrome heart defects

A

ASD, VSD, AV septal defect (endocardial cushion defect)

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3
Q

congenital rubella and the heart

A

septal defects, PDA, pulm artery stenosis

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4
Q

turner syndrome and the heart

A

bicuspid aortic valve and preductal coarctation of the aorta

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5
Q

marfan syndrome and the heart

A

MVP (mitral valve prolapse), thoracic aortic aneyrusm, and aortic regurg

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6
Q

infant of a diabetic mother

A

transposition of the great vessels

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7
Q

acute bacterial endocarditis

A

due to high virulence organism, like S. aureus. can attack normal valves. large vegitations. In IV drug users, it is likely to attack the tricuspid valve

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8
Q

subacute bacterial endocarditis

A

due to a lower virulence organism, like viridans strep. smaller vegetations on congenitally abnormal or diseased valves. gradual onset

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9
Q

culture negative bacterial endocarditis

A

most likely coxiella or bartonella (or in pathoma, HACEK organisms: hemophius, acinobacillus, cardiobacterium)

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10
Q

What bugs are especially likely to cause tricuspid endocarditis in IV drug users?

A

S. aureus, pseudomonas, C. albicans.

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11
Q

complications of bacterial endocarditis

A

chordae rupture, glomerulonephritis, suppurative pericarditis, emboli

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12
Q

rheumatic heart disease characteristics

A

evidence of prior GAS infection, as seen with an ASO titer or an anti-DNase B titer
minor criteria, like fever and elevated ESR, and major criteria: JONES: migratory polyarthritis, heart problems, subcutaneous nodules, erythema marginatum, sydenham chorea.

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13
Q

How doe people die early with rhemuatic fever?

A

myocarditis

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14
Q

What are sequelae of rheumatic heart disease?

A

valvular disease: mitral > aortic&raquo_space; tricuspid. the early lesion is likely to be mitral valve regurgitation; later lesions are due to scarring and cause mitral valve stenosis.

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15
Q

Pathologic findings of rheumatic heart disease

A

aschoff bodies (granuloma with giant cells) and anitschkow cells (enlarged macrophages with ovoid, wavy, rod-like nuclei.

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16
Q

What kind of immune reaction is rheumatic heart disease? What is the antigen?

A

type II hypersensitivity. antibodies to M protein that cross react with self antigens