heart and blood vessels Flashcards
3 forms of arteriosclerosis
Atherosclerosis
mockeberg medial calcific sclerosis
arteriosclerosis
most important form of arteriosclerosis
Atherosclerosis
ATH has intimal lesions called what?
ateheromas, athermatous plaques and fibrofatty plaques
what is the most important manifestation of
ATH
CHD
basic features at ATH?
raised focal lesion of the intima
soft yellow core of cholesterol
esters covered by a fibrous cap
Fatty streak appears first miscroscopically
components of ATH
cells: smooth muscle cells
superfiscial fibrous cap
deep fibrous cap with necrotic core of lipids and foam cells
complications of ATH
hemmorrhage into plaque rupture/ulceration/erosion superimposed thrombosis aneurysmal dilation fatty streak
fatty streak can develop into
atheroma
steps of development of ATH
chronic endothelial injury
adhesion of blood monocytes to endothelium
adhesion of platelets
migration of smooth muscle cells to media to intima
increased accumulation of lipid within the cell and outside
PT. has either benign HTN, diabetes, elderly, or benign nephrosclerosis and you see pink hyaline thickening of the walls what arteriosclerosis do they have
hyaline
PT. has malignant nephrosclerosis and you see a onion skin appearance on the walls on the lumen what arteriosclerosis does the pt. have
hyperplastic