heart Flashcards
definition of heart failure
failure of the heart to function as a pump in maintaining effective systemic circulation
3 main causes of heart failure
MI
cardiomyopathy
hypertension
3 other less common causes of heart failure
valvular problems
congenital heart defects
arrhythmias
5 factors in the pathophysiology of heart failure
increased venous return/pressure (preload) increased outflow resistance (afterload) myocardial contractility neurohormonal sympathetic activation myocardial remodelling
what is the renin-angiotensin-aldosterone-system (RAAS) and how does it relate to heart failure
heart failure causes reduced perfusion of the kidneys leading to synthesis of Renin, this activates angiotensin I which is converted to angiotensin II. angiotensin II is a vasoconstrictor and also stimulates aldosterone production. aldosterone inreases sodium retension in the kidneys while increasing potassium excretion.
this leads to a rise in plasma sodium, increased fluid retension and rise in blood pressure
what are the actions of angiotensin II
vasoconstriction aldosterone production ADH production sympathetic stimulation renal Na and water retension, and K excretion
what are the cardiac enzymes associated with heart failure
ANP
BNP
endothelin
ADH
what are the cardiac enzymes associated with myocardium damage
troponin T and I
myoglobin
creatine kinase MB
BNP
clinical symptoms of heart failure
dyspnea
tiredness
orthopnea
PND
clinical signs of heart failure
raise JVP peripheral edema dyspnea tachycardia hypotension enlarged heart/displaced apex beat heart sounds 3 + 4 bi-basal crackles pleural effusion
what type of effusion is found in heart failure
transudative pleural effusion
what is the classification used for heart failure severity
new york heart association classification
what is class IV NYHAC heart failure like
HF symptoms at rest and exacerbated by any physical activity
investigations done in HF
ECG
echo
bloods
what bloods to do in HF
FBC LFT TFT U&Es cardiac enzymes BNP