heamatology and oncology

Question 1

diagnostic test for hereditary spherocytosis

Answer 1

EMA binding test

Question 2

treatment of heriditary angiooedmea

Answer 2

Acute- IV C1 -inhibitor concentrate(to replace the deficit from the disease).
prophylaxis: anabolic steroids

Question 3

treatment of aplastic anaemia

Answer 3

• blood products
• ALG(anti-lymphocyte globulin) ATG(anti-thymocyte globulin)- can cause serum sickness(fever, rash, arthralgia)
• stem cell transplantation

Question 4

first line for immune thrombocytopenic purpura

Answer 4

oral prednisolone

Question 5

what can polycythaemia rubra vera progress to

Answer 5

• myelofibrosis

- acute myeloid leukaemia

Question 6

lymphocytic vs myeloid

Answer 6

lymphocytic-WBC raised- lymphocytosis

Myeloid- Precursors raised -RBC, WBC

Question 7

poor prognostic features of AML(3)

Answer 7

• Chromosome deletion of 5 or 7
  -> 60 years
  >20% blasts after first course of chemo

Question 8

most common type of infection with platelet transfusion

Answer 8

bacterial

Question 9

what contributes most to the increased risk of VTE in CKD

Answer 9

Anti-thrombin iii loss through nephrons

Question 10

translocation associated with Acute promyelocytic leukaemia

Answer 10

15, 17

Question 11

Wiskott-Aldrich syndrome- WaTER full form

Answer 11

Wa- wasp mutation
T-thrombocytopenia
E-eczema
R-Recurrent infections/x-linked recessive

Question 12

bone marrow disorder associated with thymomas

Answer 12

red cell aplasia

Question 13

most common electrolyte disturbance with cisplatin

Answer 13

hypomagnesemia