Clinical sciences Flashcards
what is used to detect mutated oncogenes(BRCA1)
polymerase chain reaction
which test is used to compare two sets of observations on a single sample- before and after intervention- before and after pain relief adminstration
Wilcoxon signed-rank test
Test used to compare proportions or percentages who improved followed two different interventions
Chi-squared test
Main component of endogenous lung surfactant
Dipalmitoyl Phosphatidylcholine(phospholipids)
Layers of Epidermis(CLGSB(G))
Stratum Corneum Stratum Lucidum Stratum Granulosum Stratum Spinosum Stratum Germinavatum
Which layer of epidermis are melanocytes and keratinocytes found in?
Stratum Germinavatum(basal layer)
the proportion of patients who test positive on screening and do have the condition. What is this screening measure?
Positive Predictive Value
proportion of patients who test negative on screening, and do not have the condition. What is this screening measure?
Negative Predictive Value
proportion of patients who do not have condition and test negative on the screening test. What is this screening measure?
Specificity
Proportion of patients with the condition who has a positive result
Sensitivity
Wide vermillion border, supravalvular Aortic Stenosis, flat nasal bridge, Disinhibited Friendly behaviour. Diag
Williams Syndrome- diagnosed with FISH studies
subvalvular Aortic Stenosis association
Hypertrophic Obstructive Cardiomyopathy
Valvular Aortic Stenosis
Calcification, rheumatic fever
X-linked recessive condition, deficiency in alpha-galactosidase A- burning pain/paraesthesia,dark and red painless spots on skin(angiokeratomas), Corneal Opacities, and early cardiac and renal disease
Fabry disease
Commonest chromosomal defect in Downs syndrome
Nondisjunction
Golgi Apparatus - function- the Charon of cell organelles- takes things to die
Modifies, sorts and packages molecules that are destined for cell secretion.
Adds Mannose-6-phosphate to proteins to designate transport to lysosymes
Specificity Calculation
TN/(TN+FP)
Contingency table for Specificity and Sensitivity Calculation
TN, FP
FN TP
Sensitivity Calculation
TP/(TP+FN)
Positive predictive Value Calculation
TP/(TP+FP)
Negative Predictive Value Calculation
TN/(TN+FN)
Leptin- where is it released from
Adipose Tissue
Leptin- where does it act and other functions
Satiety Centre in Hypothalamus- decrease appetitie, releases Melanocyte-stimulating hormone and Corticotrophin releasing Hormone(CRH)
C1 inhibitor deficiency causes what disease
causes hereditary angioedema
C1q, C1rs, C2, C4 deficiency causes what disease
causes immune complex disease-Henoch-schonlein Purpura
C3 Deficiency causes what disease
recurrent bacterial infections
C5 Deficiency causes what disease
Leiner disease- , recurrent diarrhoea, wasting , and seborrhoeic dermatitis
C5-9 deficiency
encodes the Membrane attack complex-prone to neisseria meningitidis infection
REM sleep associated disorders - which waves
Beta waves
incomplete paralyisis- patient kicks out and acts out their dreams- vivid intense and violent
Non - REM 1 disorder and which waves
Theta waves
Limb jerks
NON - REM2 association and which waves
50% of total sleep - sleep spindles
NON - REM 3 disorders and waves
Disorders- night terrors, nocturnal enuresis , sleepwalking
Delta waves
