Healing and Repair

Question 1

What is resolution?

Initiating factor and tissue damage/regeneration

Answer 1

Initiating factor removed
Tissue undamaged or unable to regenerate

Question 2

What is repair?

Initiating factor and tissue damage/regeneration

Answer 2

Initiating factor still present
Tissue damaged and unable to regenerate

Question 3

What is repair?

Tissue change

Answer 3

Replacement of damaged tissue by fibrous tissue

Question 4

Examples of repair

Heart, brain

Answer 4

Myocardial fibrosis after MI
Brain gliosis after cerebral infarction

Question 5

Which cells regenerate?

Answer 5

Hepatocytes
Pneumocytes
Blood cells
Epithelium (Gut, skin)
Osteocytes

Question 6

What cells do not regenerate?

Answer 6

Myocardial cells
Central neurones

Question 7

How does liver cirrhosis occur?

Answer 7

Continuous liver damage
Fibrosis
Cirrhosis

Question 8

Process of healing skin wounds - abrasion

Answer 8

Scab forms over the surface
Epidermis grows out from adnexa
Thin confluent epidermis
Epidermal regrowth

Question 9

Healing skin wounds by 1st intention

Answer 9

Edges of skin pulled together
Incision filled in by a weak fibrin joint
Fibrin replaced by collagen for a strong joint
Epidermal regrowth

Question 10

Healing skin wounds by 2nd intention

Answer 10

Edges of wound not brought together - trauma, excision etc
Loss of tissue
Granulation tissue fills in around crater with capillary loops over hole
Myofibroblasts fill in crater
Early fibrous scar
Scar contracts