Head and Neck Carcinoma Flashcards
What are differentials for a hoarse voice (dysphonia)?
Allergies and chemical/environmental irritants
Direct trauma
Infections
Laryngopharyngeal or gastrooesophageal reflux
Medications
Vocal abuse
Benign vocal fold lesions
Dysplasia and squamous cell carcinoma
Age-related vocal atrophy
MS, myasthenia gravis, Parkinsons, stroke
Acromegaly, amyloidosis, hypothyroidisim
Inflammatory arthritis, lupus, sarcoidosis
What is the anterior triangle?
- lower border of mandible
- midline of neck
- anterior border of SCM
What is the posterior triangle?
- posterior border of SCM
- anterior border trapezius
- middle part of clavicle
What are the common types of head and neck cancer?
Squamous cell carcinoma
What are the (3) main risk factors for HNSCC?
- smoking → inc x7.5
- alcohol XS → inc x6
- alcohol + smoking → inc x38
-
HPV
- HPV 16 associated w/ oropharyngeal cancer
- very common infection
- almost always cleared w/ no adverse effect
- presents in younger pts → more aggressive, increasing incidence, more amenable to treatment + vaccine available
What is the mode of spread of HNSCC?
- different to other cancers
- metastasises to cervical lymph nodes first
- hard, fixed neck lump
- still curable
- neck radiotherapy
- surgical lymph node clearance (“neck dissection”)
- distant mets usually to lung
What are the relevant investigations for suspected HNSCC?
- referral to 2-week-wait ENT clinic
- thorough ENT history + examination
- flexible nasolaryngoscopy
- CT neck + chest
- some tumours need MRI to assess extent
- lymph nodes → FNA +/- ultrasound guidance
- core or exicision biopsy risks seeding of SCC
- usually need GA to biopsy primary tumour via panendoscopy
How does nasopharyngeal cancer present?
- presents late → v poor diagnosis (50% 5 year survival)
- unilateral middle ear effusion
- epistaxis
- nasal blockage
- common in south china (salt fish diet + genetic risks)
How does oropharyngeal cancer present?
- usually tonsillar - beware asymmetric tonsils
- may be SCC or lymphoma
- consider tonsillectomy
- persistent pain in throat / ear
- feelings of lump in throat
- dysphagia
How does hypopharyngeal cancer present?
Late
50% w/ nodal metastases
5 year survival <40%
Throat/ear pain
Dysphagia
Dysphonia (late sign)
When should you suspect oral cavity cancer?
- cigar smoking + chewing tobacco/betel nut
- poor oral hygeine
- non-healing ulcer, lump or lesion
- refer if >14 days
- not always painful
Treated by maxfax - but keep an eye out!
How does parotid cancer present?
- gradually growing parotid lump
- usually always benign
- facial palsy very suspicious
- symptoms rare (late)
- trismus
- pain
- dysphagia
All parotid lumps need referral!
How does laryngeal cancer present?
- most common tumour site
- persistent unexplained hoarseness → 2-week-wait referral
- dysphagia
- throat pain
- otalgia
- cough
What causes vocal cord palsy and what are the investigations?
- recurrent laryngeal nerve dysfunction
- course of RLN - longer on right than left
- caused by: trauma, neoplasm, stroke
- investigation → nasoendoscopy, imaging whole course of RLN
Treatment option → thyroplasty, the affected cord is medialised with silastic
What causes bilateral vocal cord palsy?
What are the most common causes?
- Airway emergency
- Cords sit together, near midline
- Stridulous patient
- Most common causes → large neck tumours, thyroid surgery, idiopathic
- may need tracheostomy
- may resolve w/ time
What is the treatment for head + neck cancer?
- primarily surgical excision or radiotherapy
- chemotherapy as adjuvant treatment
- complex treatment decisions
- all cases discussed in head + neck MDT
- try to treat using consensus decision
What is discussed at the head and neck MDT?
Case history
Imaging
Histology
Treatment options
Social factors
What do the speech and language therapy teams provide?
- pre-treatment assessment + counselling
- alleviation of morbidity → esp swallowing + speech
- specialised treatments after laryngectomy
How would a patient communicate after laryngectomy?
‘Speaking valve’ gold standard of care
Allows air from trachea to neopharynx
Difficult to learn
Frequent care required
SALT input vital
Other options: electrolarynx, oesophageal speech, written communication
