Head and Neck Cancer Flashcards
Provide some information about head and neck cancer
- most commonly squamous cell carcinoma
- squamous cells form part of epithelium - cancer presents as thickening of epithelial surface
Head and neck cancer is largely a locoregional disease
- metastases less common in early stages
- not yet invaded into lymph and blood stream
- cancer cell travel via lymph system - poor lymphatic drainage from vocal folds assists in minimising the spread of the cancer from larynx in the early stages
What are the causes of head and neck cancer?
- smoking (and chewing carcinogenic substances)
- drinking
- viral causes
What are the two demographics of head and neck cancer patients?
Type 1:
- middle aged
- male: female 8:1
- heavy smoker and moderate-heavy drinker
Type 2:
- younger
- HPV+
What are the main cancer sites?
- oral and oropharnygeal
- laryngeal
- nasopharyngeal
The head and neck cancer MDT comprises the . . .
- ENT surgeon
- Plastic surgeon
- General surgeon
- Oral surgeon
- Nursing staff
- Radiation oncologist
- Medical oncologist
- Dentist
- Prosthodontist
- Radiotherapist
- Speech pathologist
- Physiotherapist
- Social Worker
- Nutrition & Dietetics
- Audiologist
- Palliative care staff
- Laryngectomy support visitor
What is the speech pathologist’s role in the MDT?
- input into treatment decisions regarding potential speech and swallowing outcomes and patient suitability to manage these
- speech and swallowing management
- pre, during and post- treatment
- patient advocacy
What are the presenting signs and symptoms of head and neck cancer?
- vocal changes (hoarseness most common)
- cough, sore throat
- pain - on swallowing
- dysphagia/chest infection
- weight loss
- halitosis
- sore in the mouth that won’t heal
- swelling/thickening
- blocked nose
- trismus (inability to open mouth)
- otalgia (pain in ear)
- dyspnoea and stridor
- visible tissue changes
How is head and neck cancer medically diagnosed?
- visual examination, direct palpation
- lymph node examination
- nasendoscopy
- panendoscopy
- ultrasound + fine needle aspiration cytology
- imaging: CT, MRI, PET, Ultrasound
Discuss TNM classification
- used to define extent and severity of cancer + used to assist treatment planning
- ‘T’ = location of primary tumour
- T0 - no tumour, T4 - massive tumour in structure examined
- ‘N’ = identifies involvement of lymph nodes in immediate region
- N0 - no nodal region, N3 - nodal metastes
- ‘M’ = indicates extent of tumour spread or metastasis
- M0 - no metastasis, M1 - distant metastasis present
What are the treatment modalities for H&N cancer?
Non-surgical techniques:
- radiotherapy
- combined chemo-radiotherapy (C-RT)
- immunotherapy
Surgical techniques:
- laser and robotic surgery
- surgery +/- reconstruction
- +/- non-surgical management
What factors influence the treatment choice?
- tumour site, type and extent
- patient suitability - health and social factors
- either a) radical/curative treatment of b) palliation
- research evidence
- personal preference/skills of surgeon/equipment/support teams available
Radical vs. palliative treatment?
Radical: aim is to achieve cure, therefore complex, time consuming and unpleasant treatments are considered to be justified
Palliative: aim to alleviate symptoms, so intervention should not produce side effects worse than the cancer is causing
How does radiotherapy kill cancer?
- Radiation causes damage to DNA in both normal & tumor cells
- If cells are unable to repair this damage in time for the next cell division then they die in mitosis (the process of cell division)
- Cancer cells, however, divide more frequently, and repair less efficiently - therefore the chances of radiation killing a malignant cell are > than for healthy cells
How is radiotherapy treatment delivered?
- if primary treatment: typically initiated as soon as possible post diagnosis
- or around 4-6 weeks post surgery once tissues healed
- daily doses delivered over 2-7 weeks
How is radiotherapy treatment dosed?
- SCC are less radiosensitive than other tumours - therefore requires a high dose for cure
- typical dose for laryngeal cancer is ~60Gy (Gy = gray, cGy = hundredths of gray) delivered in 30-35 fractions over 6 weeks
- dose and delivery change with tumour type
- more extensive tumours need more irradiation, longer time and sometimes need combination radiation and chemo
How do you plan for radiotherapy treatment?
- pre-treatment planning
- ‘shell’ planning - usually 2-3 weeks prior to starting: moulded plastic shell created to maintain patient positioning for daily radiotherapy
- some patients require dental/maxillofacial consult - removal of dental caries prior to treatment
What is chemotherapy?
- the use of cytotoxic drugs administered orally or intravenously - reach tumour (and normal tissues too!) via the bloodstream
- cytotoxic drugs are designed to interfere/disrupt and prevent DNA synthesis - therefore preventing tumour growth
- used to reduce chance of residual tumour cells from re-establishing
- chemotherapy alone has little impact
- chemotherapy used in conjunction with radiotherapy for: wide spread disease, large tumour with risk of metastasis/presence of metastasis
How is chemotherapy administered?
- in weeks prior to and/or during radiotherapy
- multiple chemo drugs may be combined
Explain, including the use of, the ‘Cetuximab’ immunotherapy treatment
- Epidermal Growth Factor (EGFR) inhibitor
- Cetuximab seeks out cancer cells, binding to EGFR, stopping uncontrolled growth in cancers with EGFR mutations
Use?
- in combination with platinum-based chemotherapy treatment for locally advanced disease
- treatment of recurrent and/or metastatic disease
Explain, including the use of, the ‘Keytruda’ (pembrolizumab) immunotherapy treatment
- helps T-cells in immune system find and fight cancer
- administered intravenously
Use?
- successful in other cancer types
- may be used either alone, or in combination with chemotherapy medicines for recurrent HNSCC and the tumour tests positive for PD-L1.
List the main surgical interventions for oral and oropharyngeal SCC
- glossectomy (partial, hemi/subtotal, total)
- floor of mouth (anterior or lateral)
- tonsillar fossa
- retromolar trigone
- palatal (hard, soft)
- pharyngal resections (anterolateral, lateral posterior)
List the main surgical interventions for laryngeal SCC
- surgery to laryngeal structures
- partial laryngeal removal
- supraglottic (removal of all structures above glottis)
- supra cricoid (removal of all structures above cricoid)
- total laryngeal removal surgery
- total laryngectomy
- pharyngolaryngectomy
What is surgical tumour removal?
- need to remove cancer + ‘safe margins’
- potential significant impact on function
- depending on the extent of the cancer spread
- tumour +/- partial cord removal
- partial larynx removal, total larynx removal
- depending on extent of surgery - reconstruction with other tissues may be required
When is laser surgery used?
- for smaller tumours
- use of a laser as the cutting tool
- needs a skilled user
- heals faster, less blood loss
- enhanced ability to manage smaller laryngeal tumours without typically managed by XRT
- eliminates added effects of XRT on tissues
When can you use Transoral robotic surgery (TORS)?
- Used for T1/T2 cancer of the oropharynx & larynx
- Benefits over traditional surgery?
- IMMEDIATE:- Faster healing, shorter stay in hospital, faster return to oral intake
- LONG TERM: If need C/RT….then….similar issues ongoing
- The angled telescopes and hypermobile operating
arms give enhancement to traditional laser surgery
Techniques - Equipment costly and training required
What is reconstruction?
- one tumour is removed, the deficit can be repaired with either primary closure of using a tissue flap
- primary closure
- remaining tissues can be pulled together
- possible for small sections of lip, tongue, soft palate
Flaps or grafts:
- required for larger deficits or when the natural movement of tissue would cause breakdown of a primary closure
Different types:
- pedicle - skin/tissue moved from one part of the body to gill deficit. Called ‘pedicle’ as one part of the flap remains attached to its original vascularisation
- microvascular - tissues, with venous and arterial supply are transplanted elsewhere in body
- composite free flaps - tissue + bone
What are some possible complications following surgery?
- slow or poor wound healing
- fistulae
- failure of tissue grafts
- recurrence
What are some possible complications following nonsurgical management?
- pain
- speech/voice
- dysphagia
- weight loss
- saliva loss
- taste
- lymphedema