HDC SIGS

Question 1

What is the pathogenesis of Hodgkin’s lymphoma?

Answer 1

Increased expression of NF-kB –> increased anti-apoptosis genes and lack of differentiation

Associated with EBV and HIV

Question 2

What is Pel-Ebstein Fever?

Answer 2

Cyclic B symptoms associated with Hodgkin’s Lymphoma

Question 3

What is the pathneumonic histology seen in Hodgkin’s Lymphoma?

Answer 3

Reed Sternburg cells - double nucleated Centroblasts

Question 4

What are the surface markers on Reed Sternburg cells in Classical Hodgkin’s Lymphoma?

Answer 4

CD15 and CD30

Question 5

What are the surface markers on Reed Sternburg-like cells in Non Classical Hodgkin’s Lymphoma?

Answer 5

CD20 and CD45

Question 6

What are the variants of Hodgkin’s Lymphoma?

Answer 6

Nodular Sclerosis - most common
Mixed Cellularity - second most common
Lymphocyte Rich - best prognosis
Lymphocyte Poor - worst prognosis

Question 7

Outline chemotherapy for Hodgkin’s Lymphoma

Answer 7

ABVD
Adriamycin (Doxorubicin)
Bleomycin
Vincristine
Dacarbazine

Question 9

What is the underlying mechanisms causing Systemic Lupus?

Answer 9

Failure of self-tolerance in B cells - defective receptor editing or elimination
Genetic factors - HLA-DR2/3
Environmental factors - UV light, drugs

Question 10

Identify the diseases

Answer 10