Hallucinogens

Question 1

LSD

Answer 1

Hallucinogens

Taken by mouth, onset < one hour, peak at 2-3 hours, duration 8-12 hours

Tolerance: occurs w/ rapid onset and offset, not typical (because people usually don’t use it enough for tolerance to be a factor)

Dependence: non-reported
Addiction: ?

Question 2

Phencyclidine

Answer 2

Hallucinogen

**Mechanism: Binds NMDA type glutamate receptor and blocks cation channel

***Effects: Varried and dose dependent = altered perception, dissociative anesthetic, tachycardia, hypertension, sweating, nystagmus (eyes moving back and forth), numbness

Side effects: mood swings, catatonia, violence, coma, psychosis

Tolerance: Some, rarely observed
Dependence: Some, mild abstinance syndrome
Addiction: ?

Question 3

Delta9 Tetrahydrocannabinol

Answer 3

Mechanism of action: Cannabinoid receptor in CNS, Gprotein-coupled receptors. Mediate inhibition of neuronal function

Effects: impairment of cognitive function
Side effects: tachycardia, reddening of conjunctiva
Very lipophilic, transformed to potent 11-hydroxy-THC

Tolerance: Rapid onset and decay
Dependence: Rare
Addiction: ?

Question 4

GHB (Gammahydroxybutyrate)

Answer 4

• Metabolite of GABA
• **Agonist of GABAb receptor (GABA-B subtype, not A)
• Anesthetic, euphoria, increased sensory perception, amnesia
• ***“Date Rape Drug” (professor said feeling “close to others” I think)
• **Withdrawal Syndrome similar to ethanol