Amphetamines Flashcards

1
Q

Amphetamines (General)

A

Uses: Mood elevation, reduce fatigue, reduce appetite

**Mechanism: Causes norepinephrine and dopamine release

Side-effects: Increased BP, rapid irregular heart beat, repeated involuntary movements, psychosis

Medical uses: Treat narcolepsy, ADHD, reduce appetite

Tolerance: very great
*Cross tolerance: To similar drugs but not cocaine
Addiction: highest and quick
Dependence: little

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2
Q

Cocaine

A
Uses:  Mood elevation reduce fatigue
Mechanism:  Inhibit update of dopamine
Side effects:  Increase BP, rapid irregular heartbeat, psychosis, panic
Medical uses:  local anesthetic (formerly)
Tolerance:  small
Cross tolerance: none
Addiction:  highest and quick
Dependence:  little
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3
Q

Nicotine

A

Uses:
Mechanism: In CNS nicotinic receptors on cells that release glutamate

Poisoning: Gneralized CNS excitation, emesis, tremor, respiratory/cardiovascular stimulation and convulsion then coma

Tolerance: some functional tolerance
Addiction: very great
Dependence: little

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4
Q

Bupropion

A

Sustained release (Zyban), antidepressant

(online it says mechanism is not known but relatively weak inhibitor of neuronal reuptake of norepinepherine and dopamine, but does NOT inhibit reuptake of seratonin….it says it can treat depression and help people quit smoking)

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