Hair growth and Pigmentation

Question 1

Grows Hair

Answer 1

Minodoxil

Finasteride

Question 2

gets rid of unwanted hair

Answer 2

Eflornithine

Question 3

Tx for pigment therapy

Answer 3

Hydroquinone/ Fluocinolone/Tretinoin
&
Methoxsalen

Question 4

topical potent vasodilator

Answer 4

Minodoxil ROGAINE–>(Lonten treats HTN)

*possible vasodilation and androgen control at the follicle

Question 5

oral drug, for hair loss and BPH

Answer 5

finasteride
1 mg/day for hair loss
5mg/day for BPH

Question 6

mow for finasteride

Answer 6

“testosterone analog”–> blocks 5 alpha reductase

• decreases scalp and serum DHT
• no effect on corticol, estrogen, prolactin, TSH, TH, PTH, or cholsterol

Question 7

side effect of propecia (finasteride)

Answer 7

loss of libido, sexual dysfunction, feminization

Question 8

finasteride not recommended for use along with what OTC agent

Answer 8

saw palmetto

Question 9

MOA for eflornithine

Answer 9

topical drug, similar to ORNITHINE DECARBOXYLASE—>decreases cell proliferation and differentiation

Question 10

only or use in chin and neck–> not to be put near eyes and mucosal surfaces

Answer 10

eflornithine

• 6-8 weeks before noticable
• not a depilatory–> continue hair removal practices as needed

Question 11

anti-trypanosoma action–> aids in sleeping sickness

Answer 11

eflornithine

Question 12

whats in tri-luma

Answer 12

Hydroquinone–> inhibits melanin formation, cant convert tyrosine to DOPA
Fluocinolone–> steroid
Tretinoin–> retinoid, increases kertinocyte growth and shedding

Question 13

tri-luma is used for

Answer 13

tx of melasma

Question 14

side effect of tri-luma

Answer 14

photosensitivity

*makes skin light and more even

Question 15

tx of vitiligo

Answer 15

Methoxsalen

Question 16

MOA for methoxsalen

Answer 16

ORAL AND TOPICAL

activated by exposure to sunlight, –> causes conjugation and cross-linking of DNA–> and cell death

Question 17

clinical course of methaoxsalen

Answer 17

delayed erythema over several weeks, increased epidermal melanization, thickening of the stratum corneum

Question 18

Methoxsalen treats what

Answer 18

vitiligo, psoriasis (symptom relief), Cutaneous t cell lymphoma (mycosis fungidoides), eczema, lichen planus, alopecia areata

Question 19

chemotherapy alopecia is____

Answer 19

drug, dose, intensity, and route-dependent