haemostasis Flashcards
anticoagulants: explain the mechanism of action of anticoagulants, including warfarin and heparin, recall indications for their use and how we measure their effects in the laboratory
1
Q
3 anticoagulants
A
heparin, warfarin, DOACs
2
Q
how does warfarin work
A
Gla domain antagonist, so diminishes number of clotting factors
3
Q
how does heparin work
A
binds to antithrombin, enhancing efficiency of thrombin and FXa inhibition (cofactor)
4
Q
how do direct oral anticoagulants (DOAC) work
A
inhibit FXa or thrombin
5
Q
when would you use anticoagulant drugs
A
when at risk of venous thrombosis
