Haemopoiesis Flashcards
What is the haemopoiesis?
The formation of blood cells
Name three granulocytes?
Neutrophils
Eosinophils
Basophils
Name the monocyte in our blood that modulate immune reactions?
Macrophages
What are the three types of lymphocyte?
B cells
T cells
NK cells
What are red cells called?
Erythrocytes
What cells are responsible for primary haemostasis?
Platelets
What is the average lifespan of a red cell?
~120 days
What is the average lifespan of a neutrophil?
~7 to 8 hours
What is the average lifespan of a platelet?
~7 to 10 days
What does ‘blast’ mean as a suffix in haematology?
A nucleated precursor cell
e.g. erythro-, myelo-
What is a megakaryocyte?
Platelet precursor that is polyploid
What is a reticulocyte?
An immediate red cell precursor
What is a myelocyte?
A nucleated precursor between neutrophils and blasts
What two subsets can haemopoietic stem cells branch off into?
Myeloid or Lymphoid
Name the 5 developmental events in haemopoiesis?
Self-renewal
Proliferation
Differentiation
Maturation
Apoptosis
Where do haemopoietic cells originate from embryonically?
The mesoderm
When does bone marrow begin haemopoiesis?
By week 16 of development
Where are the sites of haemopoiesis in the bone marrow of an adult?
Axial skeleton
Pelvis
Proximal long bones
What are the prenatal sites of haemopoiesis?
Yolk sac
Liver
Spleen
Bone marrow
Where is a bone marrow biopsy taken from in an adult?
Iliac crest / sternum
Where is a bone marrow biopsy taken from in a young child?
The anterior tibia
What is the vasculature of bone marrow?
Venous sinuses
How are venous sinuses different to capillaries?
They are larger and have a discontinuous basement membrane
What is red marrow?
Marrow that is haemopoietically active
