Haemophilia Flashcards
what is haemophilia
genetic disorder affecting clotting ability of blood
what is haemophilia A associated with
deficiency of factor VIII
what is haemophilia B associated with
deficiency of factor IX
when is haemophilia considered severe
plasma activity less than 1 IU/dL
when is haemophilia considered moderate
plasma activity between 2-5 IU/dL
when is haemophilia considered mild
plasma activity between 6-40 IU/dL
what is used to increase factor VIII in some patients with mild or moderate haemophilia
desmopressin
what is the role of DDAVP
releases bound factor VIII
what should not be used for pain management in people with haemophilia
aspirin due to the inhibitory effect on platelet aggregation
why is IDB contraindicated in patients with haemophilia
potential airway compromise due to haematoma in retromolar or pterygoid space
apart from IDB what other local anaesthetic injection requires haemostatic cover
lingual infiltration
what is Von Willebrand Disease
deficient or abnormal plasma proteins (vWF)
what is von willebrand factor
stabilises factor VIII and enables platelet interaction with blood vessel wall
what are four management strategies for haemophilia
coagulation factor replacement therapy
desmopressin to release endogenous stores
antifibrinolytic drugs
local haemostatic measures
what is coagulation factor replacement therapy
factor concentrate is administered via IV infusion and dental procedures should be performed within 30 mins of administration
