HAEMOFLAGELLATES Flashcards
CA OF CHAGAS DISEASE
TRYPONASOMA CRUZI
CA OF AMERICAN TRYPANOSOMIASIS
TRYPANOSOMA CRUZI
VECTOR OF T. CRUZI
REDUVIID BUGS
VECTOR OF T. BRUCEI
TSETSE FLY
VECTOR OF LEISHMANIA SPP.
SANDFLY
IS OF T. CRUZI
METACYCLIC TRYPOMASTIGOTES
ZOONOTIC MAMMALIAN RESEVOIR HOST OF T. CRUZI
ARMADILLOS, MARSUPIALS, RACCOONS, RODENTS, & SOME OTHER PRIMATES
4 STAGES OF DEVELOPMENT OF T. CRUZI
AMASTIGOTE
PROMASTIGOTE
EPIMASTIGOTE
TRYPOMASTIGOTE
AMASTIGOTE, PROMASTIGOTE, EPIMASTIGOTE DEVELOPS IN THE ___ OF VECTORS
MIDGUT
WHERE DOES THE METACYCLIC TRYPOMASTIGOTE DEVELOP
HINDGUT
MORPHOLOGY OF TRYPOMASTIGOTE
C SHAPED/ U OR S SHAPED WITH PROMINENT KINETOPLAST
DIAGNOSTIC STAGE OF T. CRUZI
AMASTIGOTE
FURUNCLE LIKE LESIONS ASS. WITH IDURATION, CENTRAL EDEMA & REGIONAL LYMPHADENOPATHY
CHAGOMAS
PAINLESS BIPALPEBRAL EDEMA & CONJUNCTIVITIS
ROMAÑA’S SIGN
PRIMARY ORGAN AFFECTED IN CHRONIC PHASE OF T. CRUZI
HEART
ACUTE PASE TX OF CHAGAS DISEASE
NIFURTIMOX
BENZNIDAZOLE
SIDE EFFECT OF NIFURTIMOX
WEIGHT LOSS, ANOREXIA, BEHAVIORAL CHANGES & ANTABUSE EFFECT
SIDE EFFECT OF BENZNIDAZOLE
RASHES, BONE MARROW SUPPRESION, PERIPHERAL NEUROPHATY
CA OF HUMAN AFRICAN TRYPONASOMIASIS
TRYPANOSOMA BRUCEI
CA OF AFRICAN SLEEPING DISEASE
TRYPANOSOMA BRUCEI
3RD SUBSPECIES OF T. BRUCEI
TRYPANOSOMA BRUCEI BRUCEI
T. BRUCEI BRUCEI PRIMARILY AFFECT
WILD & DOMESTIC ANIMALS
T. BRUCEI GAMBIENSE IS RESPONSIBLE FOR WHAT TYPE OF SLEEPING SICKNESS
CHRONIC SLEEPING SICKNESS–95%
RESPONSIBLE FOR ACUTE SLEEPING SICKNESS– 5%
T. BRUCEI RHODESIENSE
PRIMARY ZOONOSIS OF T. BRUCEI RHODISIENSE
CATTLE & WILD ANIMALS
RESERVOIR HOST OF T. BRUCEI GAMBIENSE
DOGS, PIGS, SHEEP
IS OF T. BRUCEI
METACYCLIC TRYPOMASTIGOTE
EARLY PHASE OF HAT
HEMOLYMPHATIC STAGE
POSTERIOR CERVICAL LN ENLARGED, NON-TENDER & HAS RUBBERY CONSISTENCY
WINTERBOTTOM’S SIGN
TRYPANOSOMAL CHANCRE IS MORE COMMON IN
GAMBIAN/CHRONIC SLEEPING SICKNESS
LATE STAGE OF HAT
MENINGOENCAPHALITIC STAGE
IT IS A DEEP DELAYED HYPERESTHESIA (BILATERAL PAIN OUT OF PROPORTION TO TISSUE INJURY)
KERANDEL’S SIGN
CONTINUOUS CHANGES IN THE SURFACE COAT WHEREIN GLYCOPROTEINS HOST’S ANTIBODIES CANNOT RECOGNIZE THE PARASITE
ANTIGENIC VARIATION
TX FOR EARLY STAGE
IV SURAMIN SODIUM- BOTH
IV PENTAMIDINE- GAMBIAN
ARSENIC CONTAINING DRUGS CAUSES
FATAL ARSENIC ENCEPHALOPATHY
HOW DO THE ARSENIC CONTAINING DRUG PREVENTED IN CAUSING FATAL ARSENIC ENCEPHALOPATHY
CO-ADMIN OF CORTICOSTEROIDS
IT IS A FEBRILE EPISODE DUE TO TRYPANOSOME LYSIS AFTER MELARSOPROL TX
JARISCH- HERXHEIMER RXN
2ND LINE OF TX. IF MELARSOPROL FAILED
NITROFURAZONE
NEWER DRUG IN TX. OF HAT THAT IS LESS TOXIC & IS ALSO USED IN EARLY STAGE
ELFORNITHINE ( EFFECTIVE ONLY FOR T. BRUCEI GAMBIENSE)
KNOWN AS DELHI BOIL BY CUNNINGHAM
LEISHMANIA SPP.
ARTHROPOD VECTOR OF OLD WORLD LEISHMANIA
SANDFLY GENERA PHLEBOTOMIS
ARTHROPOD VECTOR OF NEW WORLD LEISHMANIA
LUTZOMYIA
PRIMARY RESERVOIR IN URBAN AREAS OF LEISHMANIA
DOGS
PRIMARY RESERVOIR IN URBAN & RURAL AREAS OF LEISHMANIA
RODENTS
IS OF LEISHMANIA
PROMASTIGOTE
4 CATEGORIES OF LEISHMANIASIS
CUTANEOUS LEISHMANIASIS
DIFFUSE CUTANEOUS LEISHMANIASIS
MUCOCUTANEOUS LEISHMANIASIS
VISCERAL LEISHMANIASIS
CUTANEOUS LEISHMANIAS IS COMPARED TO WHAT LEPROSY
TUBERCOID LEPROSY
IT IS THE MOST COMMON LEISHMANIASIS
CUTANEOUS LEISHMANIASIS
IT IS A ERYTHEMATOUS PAPULE OR NODULE AT THE INOCULATION SITE
ORIENTAL BUTTON
DIFFUSE CUTANEOUS LEISHMANIASIS AKA
ANERGIC OR LEPRAMATOUS LEISHMANIAISIS
IT MAY BE INITIALLY DIAGNOSED AS LEPRAMATOUS LEPROSY & HAS A LOCALIZED, NON-ULCERATING PAPULE
DIFFUSE CUTANEOUS LEISHMANIASIS
IT IS A DISFIGURATION INVOLVEMENT OF MUCOUS MEMBRANES OF NASAL & ORAL CAVITIES/ NASAL SEPTUM DESTRUCTION
ESPUNDIA
ESPUNDIA IS A CHARACTERISTIC OF
MUCOCUTANEOUS LEISHMANIASIS
VISCERAL LEISHMANIASIS IS AKA
KALA AZAR
ACUTE PHASE OF VL/KALA AZAR
2X DAILY FEVER SPIKES (DOUBLE QUOTIDIAN) W/ CHILLS
*MISTAKEN FOR MALARIA
PHASE OF VL WITH S/S OF FEVER, WEAKNESS, LOSS OF APPETITE, WEIGHT LOSS, HEPATOSPLENOMEGALY
SUBACUTE & CHRONIC COURSE
IN LEISHMANIA SKIN TEST/MONTENEGRO SKIN TEST, THE ONLY POSITIVE IS
CL & MCL
NEGATIVE FOR DCL & VL
PRIMARY TX. OF LEISHMANIASIS
BASED ON ANTIMONY COMPOUNDS
2ND DRUG OF CHOICE FOR LEISHMANIASIS
IV AMPHOTERICIN B
LEISHMANIA IS DIVIDED INTO 2 WORLDS, WHAT ARE THE SPECIES IN OLD WORLD
L. TROPICA
L. AETHIOPICA
L. MAJOR
SPECIES IN NEW WORLD
L. MEXICANA L. AMAZONENSIS L. GUYANENSIS L. BRAZILENSIS L. CHAGASI