Haemodynamic Practical Flashcards
Infarction means?
Area of necrosis
thrombus means?
blood clot attached to the wall of a vessel or heart chamber
embolus means?
Anything undissolved travelling in the blood
aneurysm means?
localised abnormal ballooning out or dilation of part of a vessel/ventricle wall
atheroma means?
sclerotic plaque which represents an area of chronic inflammation within the wall of an artery
atherosclerosis means?
process of atheroma formation. Chronic inflammatory process within wall of artery. Typically affects intima of artery.
congestion means?
passive build-up of blood within a vessel, increasing hydrostatic pressure
oedema means?
increased fluid in interstitial tissue
effusion means?
increased fluid in body cavity
exudate means?
High protein oedematous fluid caused by increased hydrostatic pressure from hyperaemia & increased vascular permeability
Transudate means?
Low protein oedematous fluid caused by increased hydrostatic pressure &/or reduced colloidal osmotic/oncotic pressure
Haemorrhage means?
Loss of blood (all of the constituents) from a damaged vessel, the blood may be lost outside of the body, into surrounding tissue or into a body cavity
Haematoma means?
Bruise or accumulation of blood constituents in a tissue, organ or body cavity (typically used to describe a large accumulation).
a. What is the main site for haemopoiesis in the adult?
The red marrow in the axial skeleton produces red blood cells in response to erythropoietin (EPO) which is constantly released by the kidney. In response to hypoxia or low levels of RBCs, the kidneys increase the synthesis and release of EPO.
In conditions where blood is being chronically lost or RBCs are being destroyed in excessive numbers, the red marrow can expand and the spleen, liver and other organs can produce RBCs in a process known as extramedullary haematopoiesis.
b. Can you live without a spleen?
Yes and the spleen is removed in cases where there is trauma resulting in internal haemorrhage from the spleen which is a medical emergency. In addition, some autoimmune conditions involve inappropriate and excessive destruction of RBCs by the spleen which will be removed as a consequence.
The spleen filters the blood looking for antigens, recycles RBC constituents and serves are a store for platelets and monocytes. People who have a splenectomy have more RBCs with intracellular inclusions and are more vulnerable to infections. For planned splenectomies (when it is not a medical emergency) vaccinations against common bacterial infections are given a few weeks before the operation.