Haematopoesis & Myeloid Leukemia

Question 1

Draw + Outline the myeloid and lymphoid cell tree and the morphology and function of all main cells(and their presence in the blood+lifespan).

Question 2

Define ontogeny, proliferation, differentiation, and apoptosis.

Question 3

What are the components of the bone marrow?

Question 4

Hematopoietic Stem Cells are recognized by colony-forming units(CFUs) using functional assays. Define pluripotent and oliogopotent. (Also draw the appropriate image with only the main or relative cells)

Question 5

Name and outline the functions of some growth factors/cytokines.

Question 6

Explain Erythropoiesis

Question 7

Explain Granulopoiesis

Question 8

Explain Thrombopoiesis

Question 9

Explain Lymphopoiesis

Question 10

Draw/explain the patient pathway.

Question 11

Understand the molecular pathobiology of Chronic Myeloid Leukaemia (CML). (Put all leukaemias with relevant issues in a table for comparing and contrasting).

Question 12

Signalling mechanisms ?

Question 13

Outline CML staging.

Question 14

Discuss diagnosis and treatment of CML.

Question 15

Define/explain stem cell resistance.

Question 16

What is stem cell theory?