ABO + RBC Disorders

Question 1

What are the two most clinically significant and routinely checked for blood group systems?

Question 2

Explain the concept of blood groups(draw a basic membrane for aid?).

Question 3

Explain the ABO phenotype based on the genotype using a table.

Question 4

Explain the biochemical nature of ABO.

Question 5

Explain in DETAIL the entire Rh blood group system.

Question 6

Explain Rh and HDFN in DETAIL.

Question 7

RBC contain hemoglobin and act primarily as transporters—but virtue of the fact they have several membrane proteins they also have additional functions. Outline 2 other functions that are useful for RBCs.

Question 8

Several proteins act together(NOT IN ISOLATION) to form complexes in the cell membrane. Name all of these proteins and what complex’s they create/interactions…? (DRAW)

Question 9

How are erythrocytes deformed? What types of deformities exist?

Question 10

What characteristics do abnormal erythrocytes have?

Question 11

Draw/outline the erythrocytes membrane: lipids and phospholipids.

Question 12

What are the KEY COMPNENTS OF ERYTHROCUTES MEMBRANE AND MEMBRANE CYTOSKELTON (DRAW).

Question 13

Explain all the horizontal interactions with respect to the key components of the erythrocytes membrane.

Question 14

Explain all the vertical interactions with respect to the key components of the erythrocytes membrane.

Question 15

Define RBC membrane disorders.

Question 16

Define Hereditary Spherocytosis(HS) and what causes it with respect to V & H interactions.

Question 17

Define Hereditary Elliptocytosis(HE) and what causes it with respect to V & H interactions.

Question 18

What are the clinical aspects and treatments of HS and HE?

Question 19

Outline Rhnull.