HAEMATOLOGY & ONCOLOGY Flashcards
1
Q
what is the precursor amino acid of urea
A
arginine
2
Q
in CKD, platelet function is disrupted by what
A
inappropriate upregulation of nitric oxide
(as urea levels rise, arginine and precursors shunted to different pathway guarnidinsuccinic (GSA), precursor to nitrix oxide - high NO inhibits primary haemostasis
NO downregulates vWF secretion
NO reduces ADP and TXA2 levels, inhibits GpIIa/IIIb receptor
3
Q
A
