Haematology malignancy Flashcards
Which leukaemia is most common in children?
ALL
Which leukaemia is associated with warm haemolytic anaemia?
CLL
Which leukaemia has a long chronic phase, accelerated phase and blast phase?
CML
Which leukaemia is associated with Auer rods?
AML
Which leukaemia is associated with Down syndrome?
ALL
Which leukaemia has smudge and smear cells on the blood film?
CLL
What is Ritcher’s transformation?
Transformation from CLL into high grade B-cell lymphoma
Which leukaemia is associated with the Philadelphia chromosome t(9;22) (q34;q11) ?
CML
How does leukaemia present?
Fatigue
Fever
Pallor
Petechiae or bruising due to thrombocytopenia
Lymphadenopathy
Hepatosplenomegaly
Which translocation occurs in AML?
t(8;21)(q22;q22)
What is the management of CML?
Imantinib
What is the management of ALL?
Steroids, vincristine, asparaginase
What is the management of CLL?
Rituximab, ibrutinib
What is the management of AML?
Daunorubicin
What malignancy is coeliac disease associated with
Enteropathy associated T cell lymphoma
What malignancy is H. Pylori associated with?
MALT lymphoma
Risk factors for lymphoma
HIV
EBV
Autoimmune conditions
Which cancer are Reed-Sternberg cells characteristic of?
Hodgkin’s lymphoma
Describe lymphadenopathy in lymphoma
Non-tender, firm, rubbery
Hodgkin’s lymphoma - may be tender after alcohol
What is the management of non-Hodgkin’s lymphoma?
R-CHOP
Rituximab
Cyclophosphamide
Doxorubicin hydrochloride
Vincristine
Prednisolone
Which leukaemia is more predominant in older pateints?
CLL and AML
