Haematology malignancy Flashcards

1
Q

Which leukaemia is most common in children?

A

ALL

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2
Q

Which leukaemia is associated with warm haemolytic anaemia?

A

CLL

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3
Q

Which leukaemia has a long chronic phase, accelerated phase and blast phase?

A

CML

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4
Q

Which leukaemia is associated with Auer rods?

A

AML

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5
Q

Which leukaemia is associated with Down syndrome?

A

ALL

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6
Q

Which leukaemia has smudge and smear cells on the blood film?

A

CLL

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7
Q

What is Ritcher’s transformation?

A

Transformation from CLL into high grade B-cell lymphoma

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8
Q

Which leukaemia is associated with the Philadelphia chromosome t(9;22) (q34;q11) ?

A

CML

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9
Q

How does leukaemia present?

A

Fatigue
Fever
Pallor
Petechiae or bruising due to thrombocytopenia
Lymphadenopathy
Hepatosplenomegaly

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10
Q

Which translocation occurs in AML?

A

t(8;21)(q22;q22)

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11
Q

What is the management of CML?

A

Imantinib

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12
Q

What is the management of ALL?

A

Steroids, vincristine, asparaginase

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13
Q

What is the management of CLL?

A

Rituximab, ibrutinib

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14
Q

What is the management of AML?

A

Daunorubicin

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15
Q

What malignancy is coeliac disease associated with

A

Enteropathy associated T cell lymphoma

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16
Q

What malignancy is H. Pylori associated with?

A

MALT lymphoma

17
Q

Risk factors for lymphoma

A

HIV
EBV
Autoimmune conditions

18
Q

Which cancer are Reed-Sternberg cells characteristic of?

A

Hodgkin’s lymphoma

19
Q

Describe lymphadenopathy in lymphoma

A

Non-tender, firm, rubbery
Hodgkin’s lymphoma - may be tender after alcohol

20
Q

What is the management of non-Hodgkin’s lymphoma?

A

R-CHOP
Rituximab
Cyclophosphamide
Doxorubicin hydrochloride
Vincristine
Prednisolone

21
Q

Which leukaemia is more predominant in older pateints?

A

CLL and AML