Haematology Flashcards
1
Q
Polycythemia vera
A
Increase in the number of normal RBC as well as WBC and platelets
weakness, headache, light headed, visual changes, fatigue, dyspnea
eventual myelofibrosis and marrow failure
increased risk of bleeding and thrombosis
splenomegaly, macro and microvascular events, aquagenic pruritis
can cause iron deficiency
Testing for JAK2 or CALR
phlebotomy
low dose aspirin
2
Q
Acute Lymphocytic Leukemia
A
Children Failure of cell maturation--> accumulation of useless cells--> spill into blood Bone marrow failure blasts Bone marrow exam
3
Q
Acute Myeloid leukemia
A
Adults Failure of cell maturation--> accumulation of useless cells--> spill into blood Bone marrow failure blasts Bone marrow exam; auer rods
4
Q
Chronic lymphocytic leukemia
A
More common in men, over 45 years old
aneamia
painless lymphadenopathy
splenomegaly
5
Q
Chronic Myelod leukemia
A
Unrestrained excessive proliferation normal maturation age 30-80 years Philidelphia chromosome chronic, can transform to acute splenicomagaly tiredness, weightloss, SOB, abdo pain
6
Q
Hodgkin’s disease
A
Reed sternberg cells
Painless rubbery lymphadenopathy
hepatosplenomegaly
May show lymphopenia
7
Q
Non-hodgkin’s
A
Monoclonal proliferation of lymph cells lymph enlargement weight loss sweats fever itching hepatosplenomegaly
8
Q
Multiple Myeloma
A
Plasma cell proliferation bruising heart failure bony collapse anaemia bone pain and fracrues lytic lesions renal failure hypercalcemia
