Haematology Flashcards
What is Haemophilia A?
A deficiency in Factor VIII
What is Haemophilia B?
A deficiency in Factor IX
What is von Willebrand’s disease?
A quantitative or qualitative deficiency in von Willebrand Factor (vWF)
How is Haemophilia A or B inherited?
X-linked recessive
How is von Willebrand’s disease inherited?
Autosomal dominant
What haemophilia is the most common?
Haemophilia A
What is bleeding time used to assess and when is it likely to be increased?
Assesses platelet function.
Will be increased with dysfunctional platelets or thrombocytopaenia.
What coagulation factors are Vitamin K dependent?
2, 7, 9, 10
What does APTT measure?
The intrinsic coagulation cascade
What does PT/INR measure?
The extrinsic coagulation cascade
What is the most common inherited bleeding disorder?
von Willebrands disease
What happens to the following parameters in Haemophilia?
- Bleeding time
- APTT
- INR
- Platelet count
- Normal
- Increased
- Normal
- Normal
What happens to the following parameters in von Willebrand’s disease?
- Bleeding time
- APTT
- INR
- Platelet count
- Increased
- Increased or Normal
- Normal
- Normal
What happens to the following parameters in Thrombocytopaenia?
- Bleeding time
- APTT
- INR
- Platelet count
- Increased
- Normal
- Normal
- Decreased
What is the normal range for platelet count?
150-400 x 10^9/L
