Haematology Flashcards

1
Q

translocation seen in burkitts

A

c-myc

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2
Q

traetment for antiphospholipid syndrome in pregnancy

A

LMWH + aspirin

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3
Q

cells seen in G6PD

A

bite and blister

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4
Q

what is richters transformation

A

CLL transforming into high grade NHL

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5
Q

syndrome seen with burkitts

A

tumour lysis syndrome

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6
Q

treatment for PCV

A

venesect to haematocrit <0.45
aspiring
hydroxycarbamide

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7
Q

mutation in PCV

A

JAK2

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8
Q

how long does a non urgent transfusoin take

A

90-120 mins

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9
Q

treatment for ITP

A

oral prednisolone

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10
Q

DIC typical blood picture

A

derceased platelts + fibrinogen
increased PT, APTT and fibrinogen degredation products

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11
Q

progression of PCV

A

myelofibrosis or AML

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12
Q

cells seen in CLL

A

smudge / smear cells

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13
Q

which transfusions have the higher risk of bacterial contamination

A

platelet

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14
Q

what happens to reticulocytes in aplastic crisus

A

decrease

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15
Q

what happens to reticulocytes in sequestrian crisis

A

increase

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16
Q

when are haemarthroses seen

A

haemophilia

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17
Q

how to treat neutropenic sepsis

A

tazocin + piperacillin

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18
Q

cells seen in DIC

A

schistocytes

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19
Q

starry nigth

A

burkitts

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20
Q

pain on alcohol consumption

A

hodgkins

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21
Q

reed sternberg cells

A

hodgkins

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22
Q

bence jones proteins

A

multiple myeloma

23
Q

how to treat multiple myeloma

A

vinecristine + Adriamycin + dexamethasone

24
Q

how to manage bleeding on warfarin

A

vit K

25
Q

signs of tumour lysis syndrome

A

hyperkalaemia

26
Q

IgG seen in which time of haemolysis

A

warm

27
Q

CML treatment

A

imantinib

28
Q

neonatal features of G6PD

A

jaundice

29
Q

genes in sickle cell trait

A

HbAs

30
Q

deficiency in TTP

A

ADAMTs-13

31
Q

treatment of warm autoimmune anaemia

A

steroids

32
Q

cause of agranulocytosis

A

clozapine

33
Q

when is cold IgM seen

A

1-3 weeks post infectoin

34
Q

which mechanism does dabigatran have

A

direct thrombin inhibitor

35
Q

iron deficiency anaemia blood picture

A

decreased iron and ferritin, increased TIBC and transferrin

36
Q

isolated thrombocytopenia

A

ITP

37
Q

aplstic crisis cause

A

parovirus B12

38
Q

howel jolly bodies

A

coeliac

39
Q

prophylaxis of neutropenic sepsis

A

fluoroquinolone

40
Q

worst prognosis of HL

A

lymphocyte depleted

41
Q

most common HL

A

nodular sclerosis

42
Q

causes of microcytic anaemia

A

iron deficiency
anaema of CD
thalassaemia
sidero-blastic

43
Q

causes of normocytic anaemia

A

blood loss
anaemia of CD
haemoysis
anaplastic anaemia
CKD
hypothyroid

44
Q

causes of macrocytic anaemia

A

megaloblastic - B12, foalte, hyperpigmented neutrophils
normoblastic - alcohol, liver dsease, reticulocytosis, myelodysplasia, hypothyroidism

45
Q

when is cryoprecipitte used

A

DIC, liver failure, hypofibringogenaemia secondary to massive transfusion

46
Q

what is cryoprecipiatate a source of

A

factors VIII and fibrinogen

47
Q

where is B12 absorbed

A

terminal ileum via cubulin receptors

48
Q

where is folate absorbed

A

jejunum / duodenum

49
Q

which cells are seen in nodular sclerosing HL

A

lacunar

50
Q

staging for HL

A

ann arbor

51
Q

symptoms of acute haemolytic reaction

A

pyrexia, hypotension, flushing, abdo pain
within 24 hours (usually immediately)

52
Q

symptoms of febrile non haemolytic reactions

A

fever but no haemolysis

53
Q

sympotms of TACO

A

hypertensive, fluid overload, pulmonary oedema

54
Q

symptoms of anaphylaxis

A

urticaria