Haematology

Question 1

Subtype of Hodgkins lymphoma with the most favourable prognosis

Answer 1

classical lymphocyte predominant variant

Question 2

Genotype of the mild form of sickle cell

Answer 2

HbSC

Question 3

Neutropenic sepsis

Answer 3

A relatively common complication of cancer therapy, usually as a consequence of chemotherapy. most commonly occurs 7-14 days after chemotherapy. may be defined as a neutrophil count of < 0.5 * 109 in a patient who is having anticancer treatment and has one of the following:
a temperature higher than 38ºC or
other signs or symptoms consistent with clinically significant sepsis
= URGENT admission to hospital

Question 4

What is neurological signs combined with abdominal pain until proven otherwise

Answer 4

Acute intermittent porphyria or lead poisoning

Question 5

Factor V Leiden mutation (the most common inherited thrombophilia)

Answer 5

= activated protein C resistance

• most common thrombophilia
• activated factor V is inactivated 10 times more slowly than normal by protein C (hence its alternative name of activated protein C resistance).
• likely if already experienced recurrent DVTs and has a family history of thrombo-embolic events

Question 6

Protein C deficiency, Protein S deficiency, Prothrombin gene mutation (heterozygous) and Antithrombin III deficiency are all

Answer 6

Inherited thrombophilias

Question 7

Antithrombin III (ATIII)

Answer 7

A non-vitamin K-dependent protease that inhibits coagulation by inhibiting the enzymatic activity of thrombin factors II, IX, and X

Question 8

Cervix drains into which lymph nodes

Answer 8

internal iliac lymph nodes

Question 9

Anthracyclines (e.g doxorubicin)

Answer 9

stabilizes DNA-topoisomerase II complex, inhibits DNA & RNA synthesis

Question 10

Ondansetron

Answer 10

5-HT3 (serotonin) antagonist - used to treat nausea and vomiting after chemotherapy.