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MRCP > Haematology > Flashcards

Haematology Flashcards

1
Q

Spleen in sickle cell disease

A

spleen is decreased in size after six months of age, due to repeated episodes of venoocculsion and infarction, and patients often have functional hyposplenism and are recommended to take daily penicillin

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2
Q

70M on melphalan + prednisolone for multiple myeloma

Drug to increase survival?

A

Thalidomide

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3
Q

Warfarin
bleeding
INR 10

Rx?

A

Prothrombin complex concentrate + Vit K

PCC replaces F2/7/9/10

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4
Q

Indicators poor prognosis Hodgkin’s disease

A

B symptoms: FlaWS

mass >10cm

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5
Q

what is cryoprecipitate

A

fibrinogen

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6
Q

LAP score (WBC ALP)

low in

high in

A

low in CML

high in myelofibrosis, Polycythemia vera, multiple myeloma, ALL, CLL

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7
Q

MCV in haemolytic anaemia

A

high

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8
Q

give transfusions

plt over
packed RBC over

A

Plt over 30 mins

RBC over 90-120 mins

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9
Q

blood product

highest risk bacterial transmisison

A

Platelets

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10
Q

vWD inheritance

type I (commonest)

type II

type III

A

type I - AD with variable penetrance

type II - AD

type III - AR

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11
Q

Metformin effects on B12

A

B12 deficiency if taken LT

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12
Q

60F bruising
Plt 15
WCC 6
Hb 130

Dx?
Mx?

A

ITP

Give Oral Pred

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13
Q

45M Haemophilia B (F IX deficiency)

concerned about bleeding during surgery

what do you give?

A

Tranexamic acid

stops plasminogen activation, reduced plasmin and slow degradation of fibrin clots

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14
Q

chromosomal translocation t(15; 17)

Aberrant fusion of 2 genes -> leukaemogenesis

A

acute promyelocytic leukaemia

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15
Q

47F with tiredness

Hb 105
MCV 68
HbA2 high

A

B thalassemia trait

low MCV + high HbA2(2a +2d chains)

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16
Q

carbamazepine effect on warfarin

A

decreases warfarin

as enzyme inducer

17
Q

Why are CLL patients prone to chronic infections?

A

Ig deficiency

18
Q

low plts after heparin (HIT)

Rx?

A

stop heparin

start alternative anticoag - Danaparoid

19
Q

When to start chemo in CLL

A

Symptoms present

progressive lymphoctosis

wt loss >10%

20
Q

haemolytic anaemia

G6PD deficiency associated with which drugs? (nb also infection)

A

aspirin/ ibuprofen
quinine
antimalarials
sulphonamides

21
Q

MOA hydroxycarbamide in sickle cell disease

A

stimulates production fetal Hb

NB not used in acute sickle crisis

22
Q

osteomyelitis in sickle cell

organism?

A

salmonella

23
Q

idiopathic thrombocytopenic purpura - 80% actuallly are AI/ have Abs

What are Abs to?

A

IgG antibodies against platelet membrane glycoproteins IIb-IIIa or Ib-IX

24
Q

AED causing macrocytic anaemia?

A

Phenytoin (-> B12 deficiency)

MRCP (12 decks)

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