HAEMATINICS Flashcards
What are haematinics
analytes iron, cobalamin and folate
What are Haematinices important for
important markers of anaemia and can increase haemoglobin concentration
What is ferritin
major storage from of iron
where is ferritin stored and what is it composed off
composed of apoferritn and iron phosphate hydroxide core
the amount of circulating ferritin shows ?
the parallel concentration of storage iron
What is Haemosiderin
water insoluble heterogenous iron protein aggregate. long term storage iron. not readily mobilised
what colour is haemosiderin when stained with prussian blue. and when not stained
blue
golden brown
a low ferritin shows what?
iron deficiency
Borderline ferritin levels should be considered in the text of ….
CRP
what the 5 transferrin based measurements
transferrin transferrin saturation . soluble transferrin receptors . unsaturated iron binding capacity total iron binding capacity
variable affecting serum iron also affect what ?
transferrin measurements
main causes of cobalimin deficiency
Intrinsic factor impaired haptocorrin drug/ normal malabsorption in ileum inactivation of nitrous oxide inherited metabolic defect dietary but not as much as folate
folate related deficiency is caused by
mostly dietary jejunal abnormalities drug .induced malabsorption increased requirement . increased loss. acquired defects of folate metabolism. inherited metabolic abnormalities
Cobalamin and folate relate to which anaemia
macrocytic anaemia
where does megablastic name come from
consequence of appearance of BM derived progenitors