H pylori Flashcards
1
Q
what is h pylori
A
gram negative spiral bacterium
high risk of gastric cancer
2
Q
how does h pylori lead to ulcers
A
produce cytotoxins
activate inflammatory cascade
produces ureas
increase gastrin secretion increase acid secretion
3
Q
what is the MOA for cell destruction
A
penetrate mucous layer
release urease to neutralise mucosal layer and form ammonia
this leads to exposure of endothelial cells to acid - destroyed
4
Q
invasive tests
A
rapid urease test RUT
culture
histology
polymerase chain reaction PCR
5
Q
non-invasive tests
A
urea breath test
serological
stool antigen test
6
Q
Treatment of h pylori
A
antibiotic therapy and ulcer healing drugs in unison
OCA - omeprazole, clarithromycin and amoxicilin - PAC 500
OCM - omeprazole, clarithromycin and metronidazole - PAC 250 - cheaper
